2型糖尿病患者踝臂指数与尿微量白蛋白／肌酐比值的相关性

The association between ankle brachial index and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus

目的 探讨2型糖尿病（T2DM）患者踝臂指数（ABI）与尿微量白蛋白/肌酐比值（UACR）的相关性.方法 将141例2型糖尿病患者分为正常ABI组（0.9≤ABI＜ 1.4,99例）和异常ABI组（ABI＜ 0.9,42例）,分析两组的性别、年龄、病程、体重指数（BMI）、UACR、尿素氮（BUN）、总胆固醇/三酰甘油（TC/TG）、糖化血红蛋白（HbA1c）等指标.结果 与正常ABI组比较,异常ABI组患者的病程、BUN、UACR、HbA1c水平升高,两组比较差异有统计学意义（P＜0.05）.ABI与病程、UACR、BUN呈负相关（相关系数分别为-0.634、-0.757和-0.578,P均＜0.01）.结论 ABI与UACR呈负相关.异常ABI具有重要预警意义,能较早期地反映糖尿病患者肾功能的受损,对于筛查早期糖尿病肾病有重要临床意义.

Objective To investigate the association between ankle-brachial index（ABI） and urinary albumin/creatinine ratio（UACR） in patients with type 2 diabetes mellitus（T2DM）. Methods 141 patients with type 2 diabetes mellitus were divided into the abnormal ABI group （ n = 42, ABI 〈 0.9 ） and the normal ABI group （ n = 99,0.9 ≤ ABI 〈 1.4）. The gender, age, clinical course, BMI, UACR, BUN, TC/TG,HbAlc in two groups were measured. Results The differences of clinical course,BUN,UACR, HbAlc between the two groups was statistically significant（ P 〈 0.05 ）. ABI and clinical course, UACR, BUN of correlation coefficient were - 0. 634, - 0. 757, - 0. 578, and the corresponding P value was less than 0.01, with statistical significance. Conclusions The statistical analysis showed that UACR produced a negative influence on ABI. The results of abnormal ABI has an important warning. It can diagnose early diabetic kidney injury and has a very significant diagnostic for early diabetic nephropathy.