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克霉唑口腔黏附片的制备及质量评价 被引量:1

Preparation and Quality Evaluation of Clotrimazole Buccal Adhesive Tablets
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摘要 目的:制备克霉唑口腔黏附片并评价其质量。方法:采用黏膜粘着剂卡波姆(CP 934)、海藻酸钠、低黏度羧甲基纤维素钠(SCMC),用直接压片法压片制备克霉唑口腔黏附片,并对黏附片的不同参数如药物含量、体外溶胀百分率、药物体外释放度和黏附力进行评价。结果:筛选出最佳配方:克霉唑5 mg,CP 934 30 mg,SCMC 155 mg,聚乙二醇6000 40 mg,乳糖10mg,微晶纤维素8 mg,硬脂酸镁0.5 mg和阿斯巴甜2 mg。结论:成功制备了克霉唑口腔黏附片,其可用于进一步的体内、体外研究。 Objective: To prepare and evaluate clotrimazole buccal adhesive tablets. Method: The tablets were prepared by direct compression process using carbopol ( CP 934) , sodium alginate and sodium carboxymethylcellulose low viscosity ( SCMC LV ) as the main adjunvants. The quality of the tablets was evaluated by the parameters of drug content, swelling index, in vitro drug release and mucoadhesive strength. Result: The optimized formula was as follows: clotrimazole of 5 mg, CP 934 of 30 rag, SCMC LV of 155 rag, PEG 6000 of 40 rag, lactose of 10mg, microerystalline cellulose of 8 mg,magnesium stearate of 0.5 mg and aspartame of 2 mg. Con-clusion, The buccal adhesive tablets are Dreoared suceessfullv, and can be used in the further in vivo and in vitro studies.
出处 《中国药师》 CAS 2013年第4期540-543,共4页 China Pharmacist
关键词 口腔黏附片 颊吸收 黏膜粘着剂 克霉唑 Buccal adhesive tablets Buccal absorption Mucoadhesive Clotrimazole
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