鳞状上皮细胞癌抗原（SCC—Ag）检测在预测广西早期食管癌淋巴结转移中的意义

Significance of squamous cell carcinoma antigen detection in predicting lymph node metastasis of early stage esophageal cancer in Guang xi area

目的：探讨鳞状上皮细胞癌抗原（SCC—Ag）检测在预测广西早期食管癌淋巴结转移中的意义。方法：用酶联免疫（enzyme—linkedimmunosorbentassay，ELISA）法检测100例I—II期食管癌患者手术前血清中SCC—Ag水平，行手术确定淋巴结转移情况，比较不同淋巴结转移情况的SCC—Ag水平变化，并进行Logistic回归分析。结果：早期食管癌有淋巴结转移组SCC—Ag水平高于无淋巴结转移组，差异有统计学意义（p〈0．000），经Logistic回归分析，肿瘤大小、浸润深度和SCC—Ag水平是影响早期食管癌淋巴结转移的独立危险因素，应用1KOC曲线（receiveroperatingcharacteristiccurve）分析，SCC—Ag曲线下面积AUC（areundercurve）为0．748，P=0．000，95％CI：0．636-0．860，当SCC—Ag截断值为3．68ng／ml时，预测价值最佳。结论：SCC—Ag水平变化在预测早期食管癌淋巴结转移中有亏要价值．

Objective ： To investigate the Significance of squamous cell carcinoma antigen in predicting lymph node metastasis of early stage esophageal cancer. Methods ： Serum SCC-Ag level was detected with enzyme-linked immunosorbent （ELISA）in 100 cases I-II patients with esophageal cancer surgery, underwent surgery to determine lymph node metastasis, the SCC-Ag level changes of different lymph node metastasis was compared and Logistic Regression analysis. Results .. Early esophageal cancer lymph node metastasis SCC-Ag level higher than that without lymph node metastasis, and the difference was statistically significant （p 〈0.000）, Logistic regression analysis after the show, the tumor size, depth of invasion and SCC-Ag level is an independent risk factor of early lymph node metastasis, Application of ROC curve （receiver operating characteristic curve） was analyzed, the area under the SCC-Ag curve AUC （are under curve） was 0.748, P = 0.000,95% CI ：0.636-0 .860, the predictive value of the best When the cutoff value of SCC-Ag was 3.68ng/ml. Conclusions ： SCC-Ag level changes has important value in predicting early lymph node metastasis.