云南汉族脂联素基因-11377C〉G多态性特点

The single-nucleotide polymorphism of adiponectin gene -11377 C 〉 G in Yunnan Han population

目的：研究脂联素基因-11377C〉G在云南汉族人群中的基因多态性特点。方法：应用MassArray分子量阵列技术，对83例云南汉族人群脂联素基因-11377C〉G单核苷酸多态性进行检测。结果：云南汉族人群中脂联素基因-11377C〉G的cc、cG、GG基因型频率分别为46．4％、48．8％和4．8％，c、G等位基因频率分别为70．8％和29．2％。CC基因频率和c等位基因频率与国内各研究、日本人、多数高加索人间无显著性差异（P〉0．05），但明显低于南非黑人，差异存在统计学意义（P〈0．001），明显高于瑞典人群（P〈0．001）。结论：不同人种间-11377C〉G是存在种族差异性的．

Objective ： To study the single-nucleotide polymorphism（SNP） of adiponectin gene -11377 C 〉 G in Yunnan Han population. Methods： MassArray method was used to determine the distribution of allele and genotype frequencies of adiponectin gene -11377 C 〉 G. Results ： The genotype frequencies of adiponectin gene -11377 C 〉 G CC, CG, GG were respectively 46.4%, 48.8% and 4.8%; the frequency C and G allele were respectively 70.8% and 29.2%. The genotype frequency of CC and the frequency C allele were similar to all studies in domestic, Japanese and most Caucasian （ P 〉 0. 05） , but was significantly lower than Black of South African （P 〈 0.01）and significantly higher than Swedish （ p 〈 0.001 ） .Conclusions： There was difference genetics character between different ethnics in adiponectin gene -11377 C 〉 G.