埃索美拉唑对阿托伐他汀在犬体内的药动学影响

Effects of esomeprazole on pharmacokinetics of atorvastatin in dogs

目的:探讨埃索美拉唑对阿托伐他汀在犬体内的药动学影响。方法:Beagle犬8只,采用双周期双交叉试验将8只犬随机分为2组,每组4只,分别口服给药。一组单用阿托伐他汀,一组合用阿托伐他汀加埃索美拉唑,连续给药6d,采用HPLC法测定血浆中阿托伐他汀的浓度,比较2组的药动学参数。结果:两药合用时,阿托伐他汀的AUC(0-t)显著增大(P<0.05),其他药动学参数差异无显著性(P>0.05)。结论:埃索美拉唑能显著提高阿托伐他汀的生物利用度,但对其体内消除无显著影响。

OBJECTIVE To study the effects of esomeprazole on pharmacokinetics of atorvastatin in dogs. METHODS Eight Beagle dogs were randomly divided into two groups with dicycle and double cross test. One group was administrated with atorv astatin（5 mg.kg 1） for 6 days,and the other group was administrated with atorvastatin plus esomeprazole for 6 days. Plasma concentrations of atorvastatin in blood were measured by HPLC. The main pharmacokinetic parameters were calculated and compared by statistical analysis. RF_NULTS The pharmacokinetic parameters （AUC（0-t）） had statistical difference between two groups（P〈0. 05） ; The other pharmacokinetic parameters had no significant changes（P〉0.05）. CONCLUSION Esomeprazole could apparently increase the bioavilibility of atorvastatin,while they almost had no effect on drug elimination process.