洛伐他汀治疗2型糖尿病疗效观察

Effect of lovastatin on type 2 diabetes mellitus

目的探讨洛伐他汀治疗2型糖尿病（T2DM）临床疗效。方法将430例12DM患者随机分为单纯应用降糖药物（对照组，210例）和联合应用洛伐他汀（观察组，220例），对比分析血糖控制情况、血糖达标时间及胰岛素抵抗改善情况。结果观察组与对照组相比，能明显降低FBG、2hPG、HbA1c及HOMA—IR（P〈0．01），缩短血糖达标时间（P〈0．01）。结论降糖联合他汀类治疗T2DM的降糖疗效明显优于单纯应用降糖药物的降糖疗效，他汀类药物有独立于降低血脂之外的协助降糖作用。

Objective To investigate the effect of lovastatin therapy on type 2 diabetes mellitus （T2DM）clinical efficacy. Methods Four hundred and thirty cases of T2DM patients, were randomly divided into the simple application of hypoglycemic drugs group （control group, 210 cases） and the combined application of lovastatin group （ observation group, 220 cases）. The control of blood sugar, blood glucose and insulin resistance improvement of standard time was compared and analyzed. Results The observation group compared with the control group, the levels of FBG, 2 hPG, HbA1 c and HOMA-IR significantly reduced （P 〈 0. 01 ）, the time of reaching target of glucose was shorter （P 〈 0. 01 ）. Conclusions Antidiabetic drugs combined with statin therapy in the treatment of T2DM hypoglycemic was superior to the simple application of hypoglycemic drugs, statins has effect on lowering blood glucose independent of lipid lowering.