补体C3与糖尿病肾病临床病理的关系

Relationship between completement 3 and the clinical and pathological features of diabetic ne- phropathy ted Hospital China

目的探讨补体C3与糖尿病肾病临床与病理的关系。方法选择116例于郑州大学第一附属医院肾脏内科经肾穿刺活检证实为糖尿病肾病的患者为研究对象，搜集患者肾活检病理资料，分析不同肾脏病理类型补体C3沉积的阳性率；进而以补体C3为依据，分为C3阳性组和阴性纽，分别搜集两组的病史、相关实验室检查等临床及病理资料，比较不同组别患者临床和病理资料的差异。结果补体C3在糖尿病肾病不同病理类型沉积的阳性率比较差异无统计学意义（P〉0．05）；补体C3沉积阳性组在病程、24h尿蛋白定量和糖化血红蛋白均高于补体C3沉积阴性组，差异有统计学意义（P〈0．05）；补体C3沉积阳性组较阴性组有较高的活动指数（6．5±1．9vs4．5±1．2）和较低的慢性指数（4．8±1．7vs5．9±2．4），差异有统计学意义（P〈0．05）。结论补体C3在糖尿病肾病患者肾脏的沉积率较高，可能参与糖尿病肾病的发病及影响患者预后。

Objective To investigate the relationship between complement 3 and the clinical pathological features of diabetic nephropathy. Methods Pathological materials were collected from 116 patients with renal biopsy-proven diabetic nephropathy, and the deposition rate of complement 3 among different pathological types was analyzed. And then based on whether the renal biopsy speciments were deposited by complement 3, the cases were divided into two groups and the clinical pathological features between the two groups were compared. Results There was no significant difference of the deposition rate of complement 3 among different pathological types （ P 〉 0.05）. The group with complement 3 deposited has longer disease history, heavier proteinuria, and higher glycosylated hemoglobin （ P 〈 0. 05 ）. Also the group with complement 3 deposited had higher activitation index and lower chronic index （ P 〈 0. 05）. Conclusions The deposition rate of complement 3 was high in diabetic nephropathy patients, it may paticipate in the pathogenesis and affect the prognosis of diabetic nephropathy.