原发性高血压患者血清脂联素水平与IL-6的相关性

Relationship between adiponectin and interleukin-6 in patients with essential hypertension

目的:探讨高血压患者血清脂联素(adiponectin,APN)水平,以及APN与白细胞介素-6(interlectin-6,IL-6)的相关性。方法:选取原发性高血压患者60例(HT组,其中高血压Ⅰ级、Ⅱ级和Ⅲ级患者分别为20例),健康对照者20例(Control组),采用酶联免疫吸附法测定两组患者血清APN水平和IL-6水平。结果:高血压患者血清APN水平[(8.2±3.8)mg/L]显著低于健康对照组[(10.4±2.9)mg/L](P<0.05),而IL-6水平[(81±4)μg/L]高于健康对照组[(18±5)μg/L](P<0.05),APN水平与IL-6呈负相关(r=-0.782,P<0.05)。多元回归分析表明,收缩压、高血压分级和IL-6水平可显著影响原发性高血压患者血清APN水平的变化。结论:原发性高血压患者存在低脂联素血症,且与高血压严重程度密切相关。

AIM： To explore the relationship between adiponectin and interleukin-6 （IL-6） in patients with essential hypertension （EH）. METHODS： A total of 60 patients with EH （EH group, including 20 cases, respectively, of high blood pressure level 1, level 2 and level 3 ） and 20 healthy subjects （ con- trol group） were enrolled. Serum adiponectin and IL-6 concentrations were measured by enzyme-linked iramunosorbent assay. RESULTS： Serum adiponectin concentration in EH group was significantly lower than in control group [ （ 8. 2 ± 3.8 ） mg/L vs. （ 10.4 ±2.9 ） mg/L, P 〈 0. 05 ]. However, the serum level of IL-6 in the EH group was higher than in the control group [ （81 ±4） μg/L vs. （ 18 ±5） μg/L, P 〈 0. 05 ]. Serum adiponectin concentration was 0. 05）. Multiple regression analysis revealed that negatively correlated with IL-6 （ r = - 0. 782, P 〈 systolic blood pressure, severity of hypertension and IL-6 level significantly affected serum adiponectin level. ent in patients with EH and adiponectin concentration is CONCLUSION： Hypoadiponectinemia is pres- closely related with the severity of hypertension.