益生菌治疗化疗相关性腹泻的前瞻性研究

Prospective Study of the Effect of Probiotic on Chemotherapy-induced Diarrhea

目的观察益生菌对结肠癌术后患者化疗相关性腹泻的治疗效果。方法 90例结肠癌术后行化疗并出现化疗相关性腹泻的患者纳入研究,随机分为3组进行治疗:A组口服地衣芽孢杆菌胶囊及蒙脱石散,B组口服双歧三联活菌胶囊及蒙脱石散,C组口服蒙脱石散。3组中腹泻严重者均给予补液、营养支持、维持水电解质平衡等对症支持处理。观察患者治疗前后KPS评分、腹泻治疗效果的情况,并进行统计学分析。结果与结论地衣芽孢杆菌及双歧三联活菌对化疗相关性腹泻均有较好治疗效果,益生菌和蒙脱石散共同应用对化疗相关性腹泻治疗效果更明显。

Objective To study the effect of probiotic on chemotherapy-induced diarrhea（CID）in colon cancer patients.Methods 90 patients with colon cancer operated and with CID were randomly divided into three groups.Group A was treated with bacillus licheniformis capsule and montmorillonite powder,group B was treated with bifid lriple viable and montmorillonite powder,group C was treated with montmorillonite powder only.Those patients with severe diarrhea in three groups were treated with rehydration,nutritional support,maintain water and electrolyte balance.Before and after treatment by KPS score,the effect of diarrhea treatment were observed and analyzed.Results There was a good therapeutic effect of bacillus licheniformis and Bifid lriple viable on chemotherapy-associated diarrhea.Conclusion Using simultaneously probiotic and montmorillonite powder in the treatment of chemotherapy-associated diarrhea is more effective than montmorillonite powder only.