肝硬化严重程度与甲状腺激素水平相关关系

The Correlation Between Cirrhosis Severity and Thyroid Hormone Level

目的探讨肝硬化严重程度与甲状腺激素水平的相关关系。方法选取2009年6月～2012年6月肝硬化患者148例(已排除了合并原发性甲亢、甲减以及影响甲状腺激素水平的其它相关因素者,既往均无干扰素治疗史),其中Child-Pugh A级57例,Child-Pugh B级50例,Child,Pugh C级41例,均进行甲状腺激素水平检测。结果Child-Pugh A级57例患者中甲状腺激素水平异常者15例,占26.3%,Child-Pugh B级50例患者中甲状腺激素水平异常者34例,占68.0%,Child-Pugh C级41例患者中甲状腺激素水平异常者40例,占97.6%,且以TT3(血清总三碘甲状腺原氨酸)下降为主。结论肝硬化患者血清甲状腺激素水平明显低于正常人,以TT3(血清总三碘甲状腺原氨酸)下降为主,且甲状腺激素TT3降低程度与肝硬化病情的严重程度呈正相关。

Objective To investigate the relationship between liver cirrhosis severity and thyroid hormone level.Methods 148 patients with liver cirrhosis were included in this study.57 of which were assesed as Child-Pugh level A,50 as level B,and 41 as level C.All the patients were detectd thyroid hormone level.Results The abnormal rate in was 26.3% in Child A,68.0% in Child B and 97.6% in Child C.Conclusion Serum thyroid hormone level was lower in patients with cirrhosis,mainly with TT3 level.The decreasing of TT3 was related to the sererity of cirrhosis.