SNCG在胆管癌组织中的表达及其临床意义

Expression of γ-Synuclein Protein in Carcinoma of Bile Duct Tissues and Its Clinical Significance

目的观察γ-突触核蛋白(γ-synuclein,SNCG)在胆管癌及胆管正常组织中的表达,探讨SNCG在胆管癌发生、发展及浸润转移中的作用及其临床意义。方法采用免疫组化染色方法检测60例胆管癌及34例胆管正常组织中SNCG蛋白的表达情况,并分析其与胆管癌临床病理特征的关系。结果胆管癌组织中SNCG表达阳性率为73.33%(44/60),高于其在胆管正常组织中的表达阳性率(5.88%,2/34),其差异有统计学意义(P<0.01)。SNCG蛋白的表达与肿瘤的浸润深度和淋巴结转移相关(P<0.01),但与患者的年龄、性别及肿瘤分化程度无关(P>0.05)。结论 SNCG蛋白的表达与胆管癌的发生、发展和浸润转移相关,可能在胆管癌的浸润转移中发挥重要作用。SNCG有望成为新的胆管癌的肿瘤标志物,为预后判断和制定相应的治疗方案提供依据。

Objective To evaluate the expression of γ-synuclein protein （SNCG） in carcinoma of bile duct and normal bile duct tissues, and its clinical significance. Methods The expressions of SNCG were detected by SP immuno- histochemical in 60 cases of cholangiocarcinoma and 34 cases of normal bile duct tissues, and to analysis its relationship with the clinical pathological characteristics of cholangiocarcinoma. Results The positive expression rate of SNCG in carcinoma of bile duct tissues was 73.33% （44/60）, which was higher than that in normal bile duct tissues （P〈0. 01）. The positive expression of SNCG in carcinoma of bile duct tissues was correlated with the depth of tumor invasion and lymph node metastasis （P〈0. 01）, but not related to patients＇ age, gender, and the degree of tumor differentiation （P〉 0. 05）. Conclusions The expression of SNCG is correlated with the cholangiocarcinoma occurrence, development, invasion, and metastasis. SNCG plays an important role in the infiltration and metastasis of carcinoma of bile duct. SNCG is expected to become a new cancer tumor marker, which can provide a basis to prognosize and to formulate the corres- ponding therapy plan.