难治性哮喘患者肺泡灌洗液病原体培养结果分析

Analysis of pathogeny culture results of BALF in difficult-to-treat asthma patients

目的对难治性哮喘患者经气管镜肺泡灌洗液(BALF)病原体培养结果进行分析,以了解病原体分布及药物敏感性,指导抗菌药物治疗。方法选取常规治疗无效的支气管哮喘患者60例行支气管肺泡灌洗术治疗,行BALF细菌培养及药敏试验。结果 60例患者BALF细菌培养阳性32例(53.3%),其中革兰阳性球菌17例(53.1%),革兰阴性杆菌11例(34.4%),真菌4例(12.5%)。11例初始抗感染药物治疗效果不佳的患者,根据BALF培养结果调整治疗,均取得良好疗效。结论支气管哮喘患者合并感染的病原体分布与社区获得性肺炎相似,以球菌占多数,BALF培养是获得病原体的有效方法。

Objective To analyze the pathogens culture results of bronchoalveolar lavage fluid （BALF） in difficult-to- treat asthma patients, and understand the distribution and susceptibility to antimicrobial agents of pathogens to guide antibiotic treatment. Methods Sixty bronchial asthma patients with noneffetive to conventional treatment received bronchial alveolar lavage （BAL） treatment, BALF culture and sensitivity test. Results The BALF culture results were positive in 32 cases（53.3%） of 60 patients with asthma,included 17 cases of Gram-positive cocci（53.1%）, 11 cases of gram-negative bacilli （34.4%）, 4 cases of fungus （12.5%）. 11 patients, with noneffective to the initial anti-infec- tive drug treatment adjusted the treatment according to the BALF culture results,and achieved good effect. Conclu- sion The distribution of pathogens in patients with bronchial asthma coinfection is similar to community-acquired pneumonia, eoccis are in the majority.BALF culture is an effective method to find the pathogens.