摘要
目的通过检测2型糖尿病(diabetes mellitus,DM)患者总同型半胱氨酸(total homocysteine,tHcy)水平,探索其在心血管疾病(cardiovascular disease,CVD)事件中的危险性。方法选取我院2011～2012年80例2型DM患者,30例健康人作为对照,收集其临床资料并检测相关指标后进行分析。结果与正常对照组相比较,2型DM患者的体重、BMI和腰围明显增加(P<0.01)。空腹血糖、tHcy和TG明显升高(P<0.01),而叶酸和维生素B12显著减少(P<0.01)。男性tHcy水平明显高于女性患者(P<0.01),而其TG则低于女性患者(P<0.01)。结论 2型DM患者的Hcy、TG和腰围增高,而叶酸和维生素B12减少,这可能是早期CVD事件的独立危险因子。
Objective To determine the concentration of plasma total homocysteine （tHcy）, and explore its risk for car- diovascular events in type 2 diabetic individuals. Methods A total of 80 cases of type 2 diabetes mellitus were select- ed for this study in our hospital between 2011 and 2012, then healthy volunteers were included as controls. The clini- cal parameters and determined results were collected for analysis. Results Significant increases were obtained in body weight, body mass index and waist circumference （P 〈 0.01） when compared with the corresponding control values re- spectively. The fasting plasma glucose, tHcy, and triglyceride were significantly higher in the diabetes group when compared with the corresponding control values （P 〈 0.01）. The plasma folic acid and vitamin B12？were significantly reduced compared to the control values （P 〈 0.01）. The tI-Icy （P 〈 0.01） was significantly higher in the males when compared with the corresponding female value. Significant decrease was obtained in the plasma triglyceride （P 〈 0.01） in the male patients when compared with the female patients. Conclusion Our results showed increased plasma tHcy, triglyceride and waist circumference as well as decreased folic acid and vitamin B12 in type 2 diabetes mellitus. These alterations are risk factors for early CVD events.
出处
《中国现代医生》
2013年第13期85-87,共3页
China Modern Doctor
