期刊文献+

曲美他嗪治疗慢性心力衰竭疗效分析

下载PDF
导出
摘要 目的探讨曲美他嗪在治疗慢性心力衰竭中的临床疗效。方法将112例心力衰竭患者随机分为对照组和曲美他嗪治疗组。比较2组治疗前后心功能(NYHA)、N-BNP、LVEF和LVEDD,以12个月为期。结果 2组治疗后心功能改善、N-BNP降低、LVEF增加、LVEDD缩小,且治疗组疗效优于对照组。结论在常规治疗的基础上加用曲美他嗪治疗慢性心衰远期临床疗效显著。
作者 张洪
出处 《中国现代药物应用》 2013年第9期104-105,共2页 Chinese Journal of Modern Drug Application
  • 相关文献

参考文献2

二级参考文献8

  • 1Stanley WC. Changes in cardiac metabolism: a critical step from stable angina to ischemic cardiomyopathy. Eur Heart J Supplements,2001,3 ( Suppl 0) : 02-07.
  • 2Kantor PF, Lucien A, Kozak R, et aL The anfianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res, 2000, 86:580-588.
  • 3Renaud JF. Internal pH, Na^+ , and Ca^++ regulation by trimetazidine during cardiac cell acidosis. Cardiovasc Drugs Ther,1988,1:677-686.
  • 4Schiller NB, Shah PM, Crawford M, et aL Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of two-dimensional Echocardiograms. J Am Soc Echocardiogr, 1989, 2:358-367.
  • 5Aussedat J, Ray A, Kay L, et aL Improvement of long-term preservation of isolated arrested rat heart: beneficial effect of the antiischemic agent trimetazidine. J Cardiovasc Pharmacol, 1993,21 :128-135.
  • 6Brottier L, Baaxt JL, Combe C, et aL Therapeutic value of a cardioprotective agent in patients with severe isehemic cardiomyopathy. Eur Heart J, 1990, 11:207-212.
  • 7Belardinelli R, Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischemic cardiomyopathy. Eur Heart J, 2001, 22:2164-2170.
  • 8李果明,陈建英,黄石安,田丽红.曲美他嗪治疗不稳定型心绞痛的疗效观察[J].临床荟萃,2004,19(3):141-143. 被引量:17

共引文献125

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部