摘要
目的建立喷他佐辛贴剂的质量控制方法,并考察其体外透皮效果。方法以HPLC法测定喷他佐辛的含量,并测定粘附性能、含量均匀度等指标;同时对其小鼠离体皮肤透皮特性进行了测试。结果建立的HPLC法可用来测定喷他佐辛的含量,在0.1～200mg.L-1范围内线性关系良好,该贴剂具有良好的粘附性能,24h内累积渗透量为2.486mg。结论建立的方法可用于喷他佐辛贴剂的质量控制,其体外透皮效果良好。
Objective To establish a method for the quality control of pentazocine patch and study its in vitro transdermal penetration. Methods Pentazocine was determined using HPLC, and the adhesive ability, content uniformity, etc. were also tested. The transdermal penetration of the pentazocine was observed. Results The established HPLC method could be used for pentazocine determination, and the
出处
《中国药事》
CAS
2013年第4期394-397,共4页
Chinese Pharmaceutical Affairs
关键词
喷他佐辛
贴剂
质量控制
体外透皮
pentazocine patch quality control
in vitro transdermal penetration
