直肠癌组织CDX2蛋白表达及其临床意义

Expression of CDX2 Protein in Rectal Cancer and Its Clinical Significance

[目的]探讨直肠癌患者中尾型同源盒基因-2(CDX2)蛋白检测的临床意义。[方法]采用Western blot检测50例直肠癌组织及癌旁组织CDX2蛋白的表达,以20例正常直肠组织作为对照组。[结果]CDX2蛋白在癌组织中表达低于癌旁组织,且癌旁组织中表达低于对照组,差异均有统计学意义(P<0.01);CDX2蛋白在直肠癌组织中的表达与Dukes分期、组织分化、淋巴结转移和3年生存率有关,而与患者性别、年龄、肿瘤的部位及病理组织学类型无关。[结论]CDX2蛋白的表达情况可作为评估直肠癌肿瘤恶性程度、临床分期、侵袭转移及预后的参考指标。

[Purpose] To investigate protein expression of the caudal-related homeobox gene 2 （CDX2） and its clinical significance in rectal cancer. [Methods] Western blot analysis was used to detect the protein expression of CDX2 in 50 tissue samples with rectal cancer and cancer adjacent tissues ,as well as 20 samples with normal tissues from rectum as control group. [Results] The expression of CDX2 in rectal cancer tis- sues was lower than that of adjacent tissues,and the expression of CDX2 in cancer ad- jacent tissues was lower than that of the control group, both with significant differences （P〈0.01）.Expression of CDX2 in rectal cancer correlated with Dukes＇ stage,histologic differentiation,lymphatic node metastasis and 3-year survival, but had no obvious cor- relation with gender,age,site of lesion and pathologic type of the cancer patients. [Conclusion] Expression of CDX2 protein might be used to evaluate the malignancy, clinical stage, invasion, metastasis and prognosis of rectal cancer.