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ADAM17在脑胶质瘤中表达的研究 被引量：7

Expression of ADAM17 in Glioma
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摘要 [目的]探讨解聚素—金属蛋白酶17(a disintegrin and metalloproteinase 17,ADAM17)在人脑胶质瘤的表达及临床意义。[方法]采用Western blot法检测胶质瘤组织中ADAM17蛋白的表达,并分析其与胶质瘤恶性程度的相关性。[结果]正常人脑组织中ADAM17呈微量表达,人脑胶质瘤中表达增多,且随着恶性程度的提高,表达也进一步增多。低度恶性组中ADAM17的表达是正常脑组织的1.9倍,高度恶性组中的表达是正常脑组织的5.0倍,是低度恶性组的2.8倍。[结论]ADAM17可能在胶质瘤的发生、发展中发挥着一定的作用,ADAM17的检测可有助于胶质瘤恶性度分级判断。
作者 张艳 张雪鹏 吕捷 杨艳君
机构地区 河北联合大学附属医院
出处 《肿瘤学杂志》 CAS 2013年第4期307-308,共2页 Journal of Chinese Oncology
基金 河北省自然科学基金(C2010001767)
关键词 胶质瘤 解聚素—金属蛋白酶17 WESTERN BLOT
分类号 R739.41 [医药卫生—肿瘤]
  • 相关文献

参考文献9

  • 1Zhou BB, Fridman JS, Liu X, et al. ADAM proteases, ErbB pathways and cancer [J]. Expert Opin Investig Drugs,2005,14 (6): 591-606.
  • 2路延芹,赵光明,张雪鹏.ADAM17-siRNA对MCF-7人乳腺癌细胞增殖的影响[J].现代中西医结合杂志,2011,20(24):3003-3005. 被引量：9
  • 3Stone AL,Kroeger M,Sang QX. Structure-function analy- sis of the ADAM family of disintegrin-like and metallopro- teinase-containing proteins (review) [J]. J Protein Chem, 1999,18(4): 447-465.
  • 4张建成,康谊,吴刚,孙培春.去整合素和金属蛋白酶17调控胰腺癌细胞增殖凋亡的机制[J].中华实验外科杂志,2011,28(10):1716-1719. 被引量：4
  • 5McGowan PM,Ryan BM,Hill AD,et al. ADAM-17 expres- sion in breast cancer correlates with variables of tumor pro- gression [J]. Clin Cancer Res,2007,13(8): 2335-2343.
  • 6Katakowski M,Jiang F,Zheng X,et al. Tumorigenicity of cortical astrocyte cell line induced by the protease ADAMI7[J]. Cancer Sci, 2009,100(9): 1597-1604.
  • 7Wu X,Deng Y,Wang G,et al. Combining siRNAs at two different sites in the EGFR to suppress its expression,in- duce apoptosis,and enhance 5-fluorouraeil sensitivity of colon cancer cells[J]. J Surg Res,2007,138(1):56-63.
  • 8Borrell-Pages M,Rojo F,Albanell J,et al. TACE is re- quired for the activation of the EGFR by TGF-alpha in tu- mors [J]. EMBO J,2003,22 (5): 1114-1124.
  • 9McGowan PM, Ryan BM,Hill AD,et al. ADAM-17 expres- sion in breast cancer correlates with variables of tumor progression [J]. Clin Cancer Res,2007,13(8): 2335-2343.

二级参考文献18

  • 1Black RA, Rauch CT, Kozlosky C J, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature, 1997,385:729-733.
  • 2Andreas G, Stefan H, Oliver M, et al. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J,2003,22:2411-2421.
  • 3Wu E, Croucher PI, McKie N, eta]. Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies. Biochem Biophys Res Commun, 1997,235:437-442.
  • 4Zhang Q, Thomas SM, Lui VW, et al. Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proe Natl Aead Sei USA,2006, 103 : 6901-6906.
  • 5McCullocb DR, Harvey M, Herington AC. The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone. Mol Cell Endocrinol,2000,167 : 11-21.
  • 6Kenny PA. TACE : a new target in epidermal growth factor receptor dependent tumors. Differentiation,2007,75:800-808.
  • 7Sternlicht MD, Sunnarborg SW. The ADAM17-amphiregulin-EGFR axis in mammary development and cancer. J Mammary Gland Biol Neoplasia,2008,13 : 181-194.
  • 8Sallmann FR, Bourassa S, Saint-Cyr J, et al. Characterization of antibodies specific for the caspase cleavage site on poly ( ADP-ribose ) polymerase:spccific detection of apoptotic fragments and mapping of the necrotic fragments of poly(ADP-ribose) polymerase. Biochem Cell Biol, 1997,75:451-456.
  • 9Garton KJ, Cough PJ, Blobel CP,et al. Tumor necrosis factor-alpha- convening enzyme ADAM17) mediates the cleavage and shedding of fractalkine ( CX3CL1 ) [ J ]. J Biol Chem, 2001,276 (41) : 37993 - 38001.
  • 10Black RA,Rauch CT, Kozlosky CJ,et al. A metalloproteinase disin- tegrin that releases tumour-necrosis factor-alpha from cells[ J']. Na- ture, 1997,385 (6618) :729 - 733.

共引文献11

同被引文献48

  • 1丁翔,杨连粤,黄耿文,王伟,鲁伟群.ADAM17 mRNA在孤立性大肝癌中的表达及其意义[J].中华肝胆外科杂志,2005,11(8):544-546. 被引量：18
  • 2任琼珍,钱志红,胡建铭.Ki67在卵巢癌中的表达及临床意义[J].苏州大学学报（医学版）,2006,26(2):321-321. 被引量：9
  • 3Yamamoto K,Trad A ,Baumgart A, et al. A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells[ J]. Biochem J, 2012,445.( 1 ) : 135 - 144.
  • 4Narita D, Seclaman E, Ursoniu S, et al. Increased expression of ADAM12 and ADAM17 genes in laser - capture microdissected breast cancers and correlations with clinical and pathological characteristics [ J ]. Acta Histo- chem, 2012,114(2) :131 - 139.
  • 5Shou ZX, Jin X, Zhao ZS. Upregulated expression of ADAM17 is a prog- nostic marker for patients with gastric cancer[ J ]. Ann Surg, 2012,256 (6) :1014 - 1022.
  • 6Zheng X, Jiang F, Katakowski M, et al. ADAM17 promotes glioma cell malignant phenotype[ J]. Mol Carcinog, 2012,51 (2) :150 -164.
  • 7Xiao LJ,Lin P,Lin F,et al. ADAM17 targets MMP-2 and MMP-9 via EGFR-MEK-ERK pathway activation to promote prostate cancer cell in- vasion[ J]. Int J Oncol, 2012 ,40(5) :1714 - 1724.
  • 8Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disinte- grin that releases tumour-necrosis factor-alpha from cells [ J ]. Nature, 1997,385 (6618) :729 -733.
  • 9SINNATHAMBY G, ZERFASS J, HAFNER J, et al. ADAM met- allopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers[J]. Clin Exp Immunol, 2011, 163(3) : 324 -332.
  • 10MITRANOT I, GROB M S, CARRION F, et al. Culture and characterization of mesenchymal stem ceils from human gingival tis- sue [ J ]. Periodontol, 2010, 81 (6) : 917 - 925.

引证文献7

二级引证文献21

肿瘤学杂志
2013年 第4期

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