用NMR确定MCYST-LR环肽部分的结构

STRUCTURE OF THE CYCLO HEPTAPEPTIDE IN MICROCYSTIN-LR DETERMINED BY NMR

利用一维和二维核磁共振技术对从鱼塘水华样品中提取的一种毒素进行了研究 ,结合其它分析手段 ,确定了该毒素即为普通环七肽肝毒素Microcystin LR (MCYST LR) ,测定了该环七肽的环上氨基酸残基的连接方式和顺序 .

A toxin isolated from waterbloom of the colonial cyanobacterium \%Microcystis aeruginosa\% collected in a fish pond was studied by one dimensional and two dimensional nuclear magnetic resonance techniques. Combined with other analytical techniques, it is shown that this toxin is just microcystin LR, the most common cyclo heptapeptide. The connectivity of amino acids in the cyclic part of this toxin is determined. \;