老年医学科住院患者358例抗菌药物使用情况调查分析

Survey and analysis of antibiotics use of 358 cases of elderly inpatients in geriatric medicine department

目的了解老年医学科抗菌药物临床使用情况,促进抗菌药物的合理使用。方法抽取383份完整出院病历,对患者的基本情况、抗菌药物使用情况、病原菌种类及不良反应等进行分析。结果抗菌药物使用率为93.47%(358/383),常用药物为头孢他啶、左氧氟沙星、阿洛西林、哌拉西林/舒巴坦、依替米星、头孢地嗪、莫西沙星、阿奇霉素、氨曲南、美罗培南;病原菌送检率为例46.93%(168/358),阳性检出率为46.50%;不良反应发生率为5.59%(20/358)。结论由于老年人机体生理功能的衰退以及并发症频率的增高,且针对老年人的临床试验较少,故抗菌药物选用时需谨慎。

Objective To investigate clinical use of antibiotics in geriatrics medicine department and promote the rational use of antibiotics.Methods 383 medical records of patients who had discharged from hospital were randomly selected.The basic conditions of the patients,use of antibiotics,pathogens and adverse reactions were analyzed.Results 93.5% （358/383） of the patients used antibiotics.Ceftazidime,levofloxacin,azlocillin,piperacillin/sulbactam,etimicin,cefodizime,moxifloxacin,azithromycin,aztreonam,meropenem were commonly used.The censorship rate of pathogen was 46.9% （158/358） and the positive rate was 46.5%.The adverse reaction rate was 5.59% （20/358）.Conclusion As the decline of physiological function and increased frequency of complications of the elderly,and clinical tests targeted at the elderly patients are few,so the use of antibiotics need to be cautious.