期刊文献+

雷帕霉素的研究进展及临床应用 被引量:6

下载PDF
导出
摘要 雷帕霉素(rapamycin,RAPA)是一种新型大环内酯类免疫抑制剂。最新研究表明:RAPA通过不同的细胞因子受体阻断信号传导,阻断T淋巴细胞及其他细胞由G1期至S期的进程,从而发挥免疫抑制效应。RAPA已通过美国食品和药品管理局(FDA)认证,临床上表现出强大的免疫抑制作用,
出处 《临床合理用药杂志》 2013年第8期163-164,共2页 Chinese Journal of Clinical Rational Drug Use
  • 相关文献

参考文献9

  • 1Kikuchi Y,Imakiire T,Yamada M,et al. Mizoribine reduces renal injury and macrophage infiltration in non-insulin-dependent diabetic rats [ J ]. Nephrol Dial Transplant,2005 ,20(8) :1573 - 1581.
  • 2Wolf G, Chen S,Ziyadeh FN. From the periphery of the glomemlar capil- lary wall toward the center of disease :podocyte injury comes of age in di- abetic nephropathy[ J]. Diabetes,2005,54(6) : 1626 - 1634.
  • 3Zhang Q,Kelly AP,Wang L,et al. Green tea exact and ( - )-epigallo- catechin-3-gallate inhibit mast cell-stimulated type I collagen expressionin keloid fibroblasts via blocking PI-3K/AkT signaling pathways [ J ]. J Invest Derrnatol,2006,126 (12) :2607 - 2613.
  • 4Bonegio RG, Fuhro R, Wang Z, et al. Rapamycin amehorates proteinuria- associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy [ J ]. J Am Soc Nephro1,2005,16 (7) : 2063.
  • 5Alperovich G, Rama I, Lloberas N, et al. New immunosuppresor strategies in the treatment of murine lupus nephritis I J]. Lupus,2007, 16 (1): 18 - 24.
  • 6Ramos-Barr6n A, Pinera-Haces C, G6mez-Alamillo C, et al. Prevention of routine lupus disease in (NZBxNZW) F1 mice by sirolimus treatment [ J ]. Lupus,2007,16 (10) :775 - 781.
  • 7Laplante M, Sabatini DM. mTOR signaling at a glance [ J ]. J Cell Sci, 2009,122 ( Pt 20) :3589 - 3594.
  • 8张慧敏,韩雅玲,陶杰,闫承慧.雷帕霉素对内皮细胞迁移和血管内皮生长因子表达的影响[J].现代生物医学进展,2011,11(22):4209-4211. 被引量:2
  • 9Cho ME, Hurley JK, Kopp JB. Sirolimus therapy of focal segmental glo- merulosclerosis is associated with nephrotoxicity [ J ]. Am J Kidney Dis, 2007, 49(2) :310 -317.

二级参考文献11

  • 1Rosner D, McCarthy N, Bennett M. Rapamycin inhibits human in stent restenosis vascular smooth muscle cells independently of pRB phos- phorylation and p53 [J]. Cardiovasc Res, 2005 (66):601-610.
  • 2Rhoads JM, Niu X, Odle J,et al. Role of mTOR signaling in intestinal cell migration[J]. Am J Physiol Gastrointest Liver Physiol, 2006(291): G510-517.
  • 3Jacinto E, Loewith R, Schmidt A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive [J]. Nat Cell Biol, 2004(6): 1122-1128.
  • 4Steffel J, Latini RA, Akhmedov A, et al. Tanner. Rapamycin, but not FK-506, increases endothelial tissue factor expression: implications for drug-eluting stent design[J]. Circulation,2005(112):2002-2011.
  • 5Laplante M Sabatini, DM. mTOR signaling at a glance [J]. J Cell Sci, 2009(122):3589-3594.
  • 6Mehilli J, Kastrati A, Wessely R, et al. Randomized trial of a nonpoly- mer-based rapamycin-eluting stent versus a polymer-based paclitaxel- eluting stent for the reduction of late lumen loss[J]. Circulation, 2006 (113):273-279.
  • 7Marx SO, Marks AR. Bench to bedside: the development ofrapamycin and its application to stent restenosis [J]. Circulation, 2001 (104): 852-855.
  • 8Villaume K, Blanc M, Gouysse G, et al. VEGF secretion by neuroen- docrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway [J]. Neuroendocrinology, 2010 (91): 268-278.
  • 9Frost P, Shi Y, Hoang B, et al. AKT activity regulates the ability of mTOR inhibitors to prevent angiogenesis and VEGF expression in multiple myeloma cells[J]. Oncogene, 2007(26):2255-2262.
  • 10Kanno S, Oda N, Abe M, et al. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascu- lar endothelial cells[J]. Oncogene,2000(29):2138-2146.

共引文献1

同被引文献55

引证文献6

二级引证文献11

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部