米索前列醇联合卡前列素氨丁三醇预防高危妊娠产后出血效果观察

Clinical observation of misoprostol combined with carboprost tromethamine in prevention of high-risk pregnance postpartum hemorrhage

目的探讨米索前列醇联合卡前列素氨丁三醇预防高危妊娠产后出血的效果。方法将80例宫缩乏力性产后出血高危因素产妇随机分为治疗组和对照组各40例。治疗组剖宫产术中胎儿娩出后立即于肠壁处放置米索前列醇片0.2mg;同时子宫肌内注射卡前列素氨丁三醇250μg。对照组单纯放置米索前列醇片。观察2组第三产程时间、产后2h和24h出血量、产后出血发生率和不良反应情况。结果治疗组第三产程时间短于对照组,产后2h及24h出血量少于对照组,产后出血发生率低于对照组,差异均有统计学意义(P<0.01)。结论米索前列醇联合卡前列素氨丁三醇预防治疗宫缩乏力性产后出血效果显著,安全性好,有临床推广价值。

Objective To observe the effect of misoprostol combined with carboprost tromethamine in prevention of highrisk pregnance postpartum hemorrhage. Methods 80 cases women with high-risk of contractions fatigue hemorrhage were randomly divided into treatment group and control group, each of 40 cases. Treatment group were given misoprostol tablet 0. 2mg in the intestinal wall place and carboprost tromethamine 250μg uterine intramuscular injection after the delivery of fe- tus, and control group were given misoprostol tablets only. Observed the third stage labor time,2h and 24h bleeding amount and incidence rate of postpartum hemorrhage between 2 groups. Results The third stage labor time of observation group was shor- ter than that of control group ;2h and 24h bleeding amount of observation group was less than that of control group;Incidence rate of postpartum hemorrhage of observation group was lower than that of control group, the difference were statistically signifi- cant （P 〈 0.01 ）. Conclusion Misoprostol combined with carboprost tromethamine in prevention of high-risk pregnance post- partum hemorrhage is effective, safe,and has clinical promotion value.