中医药在抗肝纤维化过程中对病理性血管新生干预作用的研究进展

Progress about inhibitory effects against pathologic angiogenesis during process of liver fibrosis with traditional Chinese medicine

肝纤维化的发生机制非常复杂,越来越多的研究表明病理性血管新生加速了肝纤维化的进程,甚至促进了肝硬化的发生。临床上中医药在肝纤维化和肝硬化的治疗中优势明显,但其作用机制及作用靶点尚不明确。通过对近十年来相关中医药抗肝纤维化的机制文献研究分析,从中医药逆转肝纤维化过程中肝窦毛细血管化、血管生成关键因子过度表达的角度阐释其抗肝纤维化的作用机制。

Mechanism of liver fibrosis is very complex, a growing number of studies have shown that pathological an- giogenesises speed up the process of liver fibrosis, and even contribute to the occurrence of liver cirrhosis. Traditional Chinese medicine has obvious advantage in the treatment of hepatic fibrosis and cirrhosis, but its mechanism and tar- gets are not clear. The paper analyzes the last decade-related study on the mechanism against hepatic fibrosis with traditional Chinese medicine and interprets its mechanism of anti-hepatic fibrosis basing on inhibiting the formation of hepatic sinusoid capillatization and the excessive expression of angiogenesis key factors.