新辅助化疗在乳腺癌患者中应用的有效性研究

The efficacy analysis of neoadjuvant chemotherapy in breast cancer patients

目的研究新辅助化疗在乳腺癌患者中应用的有效性,为乳腺癌的治疗提供临床依据。方法 2008年1月～2010年1月来本院进行住院治疗的120例乳腺癌患者随机分为治疗组和对照组各60例,其中治疗组给予新辅助化疗后进行手术治疗,对照组只进行手术治疗。结果术后3个月和术后6个月治疗组CR比例明显高于对照组差异有统计学意义(P<0.05),而对照组PD比例明显高于治疗组,差异具有统计学意义(P<0.05),并且两组患者的局部复发、远处转移、总生存比例、无瘤生存比例差异均无统计学意义(P>0.05)。结论新辅助化疗能明显提高手术治疗的临床疗效,但是对于远期生存率的改善情况应当进一步研究。

Objective To investigate neoadjuvant chemotherapy in breast cancer patients, and provide clinical basis for the treatment of breast cancer. Methods One hundred and twenty cases of breast cancer patients who hospitalized in our hospital from 2008 January to 2010 January were randomly divided into treatment group and control group with 60 cases in each group. Operation treatment of the treatment group was given after neoadjuvant chemotherapy, the control group only given operation treatment. Results The CR rate in treatment group 3 months and 6 months after operation treatment was obviously higher than that of control group, the differences were statistically significant （P 〈 0.05）. while PD rate of the control group was obviously higher than that of the treatment group, the difference was statistical significance （P 〈 0.05）. And local recurrence, distant transfer, proportion of overall survival, disease-free survival rate of two groups were not significantly different （P 〉 0.05）, Conclusion Neoadjuvant chemotherapy can improve the clinical curative effect of operation treatment, but should be further investigated for improved long-term survival.