丁二磺酸腺苷蛋氨酸肠溶片治疗妊娠期肝内胆汁淤积症临床观察

Clinical observation of succinic acid adenosine methionine enteric-coated tablet in treatment of intrahepatic cholestasis during pregnancy

目的观察丁二磺酸腺苷蛋氨酸肠溶片(SAMe)治疗妊娠期肝内胆汁淤积症(ICP)的临床效果。方法将52例ICP患者随机分为观察组和对照组各26例。2组均予维生素C及能量合剂,在此基础上观察组予SAMe静脉滴注,对照组单纯予熊去氧胆酸(UDCA)口服。比较2组治疗前后瘙痒评分及血胆汁酸(TBA)、血清总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)水平。结果治疗后,2组瘙痒评分及TBA、TBIL、ALT水平均降低,且观察组低于对照组,差异均有统计学意义(P<0.05)。结论 SAMe治疗ICP效果显著,值得临床推广应用。

Objective To observe the clinical effect of succinic acid adenosine methionine enteric-coated tablet （SAMe） in treatment of intrahepatic cholestasis during pregnancy（ICP）. Methods 52 cases patients with ICP were randomly divided into observation group and control group, each of 26 cases. Both of 2 groups were given vitamin C and energy mixture, on that basis,observation group were given SAMe, and control group were treated with oral administration of ursodeoxycholic acid（UDCA）. Pruritus score and the level of total bite acids （TBA）, serum total bilirubin （TBIL）, alanine aminotransferase （ALT） of 2 groups were compared before and after treatment. Results After treatment,pruritus score and level of TBA, TBIL, and ALT in both groups were lower than before treatment, and observation group were lower than those of control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion SAMe in treatment of intrahepatic cholestasis during pregnancy is effective, and worthy of clinical application.