D-二聚体联合C反应蛋白监测在急性胰腺炎临床分型及严重程度评估中的意义

Application of D-dimer and CRP levels in assessment of type and severity for acute pancreatitis patients

目的研究D-二聚体及C反应蛋白(CRP)与急性胰腺炎的分型、严重程度及预后是否存在相关性,以探讨D-二聚体水平联合CRP在急性胰腺炎患者分型及严重程度评估中的价值。方法选择2008年1月—2012年11月入院的急性胰腺炎患者80例,其中重症急性胰腺炎(SAP)25例,轻症急性胰腺炎(MAP)55例。随机选取同期因腹痛入院的非急性胰腺炎患者40例为对照组。检测不同时间点患者D-二聚体、CRP在外周血中表达水平,并进行相关性研究分析。结果 SAP组CRP水平显著高于MAP组及对照组,且在入院7 d内一直保持较高水平。SAP组各时间点D-二聚体浓度水平显著高于MAP(P<0.05)。在入院3 d内MAP组CRP浓度水平亦高于对照组(P<0.05);SAP组D-二聚体值与CRP存在正相关。结论 D-二聚体联合CRP能够作为急性胰腺炎患者分型的重要标志物,能较好地判断患者严重程度,具有重要的临床应用价值。

Objective To investigate D - dimer and c - reactive protein（CRP） in patients with acute pancreatitis（AP）, so as to evaluate their predictive value and assess the severity in early typing of AP. Methods The level of CRP and D- dimer were determined in 80 patients who were admitted at different time. The correlation between determined results and clinical typing （SAP or MAP） were analyzed. Results The levels of CRP and D- dimer in patients of the SAP group were significantly higher than those of the MAP group and the control group. The expression of D- dimer was correlated with CRP in blood. Conclusion The monitoring of CRP and D- dimer levels may be helpful for AP evaluation in clinical practice.