合肥市2003～2012年流脑菌群变迁分析

Analysis of serogroup changing of neisseria meningitidis strains in Hefei,2003-2012

目的了解合肥市流行性脑脊髓膜炎(简称流脑)菌群变迁情况,为流脑防治工作提供依据。方法对合肥市2000年至2012年流脑疫情和健康人群监测资料进行回顾性分析。结果 2003年前,流脑病人主要由A群脑膜炎奈瑟菌引起(Nm)。健康人群带菌主要是B群Nm,其次为A群。2003～2012年流脑患者菌群,C群占93.0%,A群占6.0%,B群和W135占1.0%;健康人群带菌以C群和B群为主,分别为2.5%和1.6%。2011年出现由W135群引起的流脑死亡病例。结论 2003～2012年,合肥市流脑流行优势菌群从A群Nm转变为C群,C群菌群Nm仍将在一段时间内是优势菌群,而W135群和B群为辅。

Objective To investigate epidemiological trend of serogroup change of neisseria meningitidis strains in Hefei, and provide the basis for prevention and control of epidemic cerebrospinal meningitis. Method The data of epidemic cerebrospinal meningitis from patients and health population in Hefei during 2000 to 2010 were retrospectively analyzed. Results Before 2003, neisseria meningitidis strains were mainly composed of serogroup A in patients, and neisseria men- ingitidis strains from patients were mainly composed of serogroup B and A in health population. During 2003 -2012, neis- seria meningitidis strains were composed of serogroup C （93.0% ） , serogroup A（6.0% ） , serogroup B and W135 { 1.0% ） in patients, and neisseria meningitidis strains were composed of serogroup C （2.5%） and B（ 1.6% ） in health population. There was an death case caused by serogroup W135 in 2011. Conclusion Since 2003, dominant serogroups of neisseria meningitidis were changed from A to C. Serogroup C will be dominant serogroup, and B and W135 will be secondary in a period of time.