盐酸米诺环素治疗小儿肺炎支原体肺炎的临床观察

The Clinical Analysis of the Minocycline Hydrochloride Treatment for Children with Mycoplasmal Pneumonia

目的探讨盐酸米诺环素对小儿肺炎支原体肺炎的治疗效果。方法北京朝阳医院儿科病房于2010年9月-2011年11月住院的8岁以上肺炎支原体肺炎59例,随机分为2组,抗生素分别应用盐酸米诺环素(试验组)与阿奇霉素(对照组)治疗,其它治疗措施两组相同。观察两组患儿在症状、体征及辅助检查的变化并作比较。结果试验组在改善咳嗽、咯痰、肺部体征及胸部X线异常等方面均优于对照组(P<0.05)。试验组有效率96.4%,对照组有效率64.6%,试验组与对照组的疗效有明显差异(P<0.05)。结论应用盐酸米诺环素治疗年龄大于8岁的小儿肺炎支原体肺炎有明显的疗效,在治疗期间未发生不良反应病例,提示盐酸米诺环素在治疗8岁以上小儿难治性肺炎支原体肺炎方面具有较好的临床应用价值。

Objective TO investigate the treatment effect of Minocychne Hydrochloride for children with mycoplasmal pneumonia. Methods 59 eases of children who were clearly diagnosed as mycoplasmal pneumonia from September 2010 to November 2011 in our hospital were divide randomly into two groups. The treatment group is given minocychne hydrochloride per os while the control group is given the azithromycin infusion by intravenous drip, and other treatments are the same, then observe and compare the change of symptom, physical signs and auxiliary examination. Results The treatment group is obvious better than control group in aspects such as improving the symptoms of cough, phlegm, physical signs of lung and chest X - ray examination. The effectiveness of minocycline hydrochloride group is 96.4%, the effectiveness of azithromyein group is 64.6%, the two groups have significant difference （ P 〈 0.05）. Conclusions The minocychne hydrochloride treatment has obvious effect for mycoplasmal pneumoniain of children older than eight and without one adverse effect case, which indicates the clinical application value of minocycline hydrochloride in the treatment of mycoplasmal pneumonialn of children older than eight.