湿热消汤对ⅢA型前列腺炎患者前列腺液细胞因子的影响

Effects of Shirexiao decoction on cytokines of ⅢA prostatitis

目的:观察湿热消汤对ⅢA型前列腺炎患者前列腺按摩液中IL-1β、IL-6和TNF-α水平的影响。方法:将120例ⅢA型前列腺炎患者随机分为治疗组和对照组,分别给予湿热消汤和银花泌炎灵片口服,以28天为1疗程。观察治疗前后各组患者前列腺按摩液中IL-1β、IL-6和TNF-α水平的变化情况。结果:疗程结束后,与治疗前比较两组患者前列腺按摩液中IL-1β、IL-6和TNF-α水平明显降低(P<0.01);与对照组比较,治疗组优于对照组(P<0.05,P<0.01)。结论:湿热消汤可降低ⅢA型前列腺炎患者前列腺按摩液中IL-1β、IL-6和TNF-α水平,这可能是湿热消汤治疗ⅢA型前列腺炎的机理之一。

Objectives： To observe the therapeutic effect of Shirexiao decotion on IL - β, IL -6 and TNF - α levels in the massage fluid from the patients with Ill A prostatitis. Methods： 120 cases of llIA prostatitis were randomized into treatment group and control group, which were treated with Shirexiao decotion and Yinhua Miyanling tablets respectively. The IL -β ,IL -6 and TNF - α levels were detected by ELISE after 28 days. Results： After a course of treatment, the IL - β, IL - 6 and TNF - α levels were significantly decreased（ P 〈 0. 01 ）. The IL - β, IL - 6 and TNF - α levels of treatment group decreased more than those of the control group（ P 〈0. 05, P 〈 0.01 ）. Conclusion： Shirexiao decotion is effective in decreasing IL- β ,IL- 6 and TNF - α levels of Ⅲ A prostatitis, which is likely to be the mechanisms of Shirexiao decoction in treating Ⅲ A prostatitis.