高血压并心、脑、肾损害患者血浆5-羟色胺和去肾上腺素的变化

Clinical significance of the levels of 5-HT、5-HIAA、norepinephrine in patients with essential hypertension

目的 :探讨高血压病患者 5 -羟色胺 (5 - HT)变化与临床的关系。方法 :用荧光法测定 172例高血压病不同病程患者血浆 5 - HT,5 -羟吲哚乙酸 (5 - HIAA) ,去甲肾上腺素 (NE)水平。结果 :高血压病患者血浆 5 - HT、5 - HIAA、 NE水平显著高于对照组 (P<0 .0 1) ,5 - HT与平均动脉压呈显著正相关性 ,高血压合并脑出血、尿毒症患者 5 - HT增高尤为显著 (P<0 .0 0 1)。结论 :本研究提示 ,5 - HT水平升高在高血压病并心、脑。

Objective:To study clinical significance of the levels of 5 HT(5 hydroxytryptamine)、5\|HIAA(5\|hydroxyindoleacetic acid)、norepinephrine(NE) in patients with essential hypertension.Methods:The plasma levels of 5 HT,5 HIAA and NE were measured in 172 patients with different patterns of hypertension by flurometry.Results:The plasma levels of 5 HT and 5 HIAA were significantly higher in patients with hypertension than those of control group( P <0 01).5 HT concentration correlated positively with mean arterial pressure.The increase level of 5 HT was most prominent in patients with hypertension associated cerebral stroke,uraemia( P <0 001).Conclusion:This study indicates that the increase of levels 5 HT may play an important role in essential hypertension. Author′s address People Hospital of Xiangzhou District,Zhuhai,Guangdong,519090