奥沙拉嗪联合氢化可的松灌肠治疗溃疡性结肠炎疗效观察

Therapeutic effect of Olsalazine combined with hydrocortisone on active ulcerative colitis

目的奥沙拉嗪和氢化可的松是治疗溃疡性结肠炎的常用药物,本文目的是研究使用奥沙拉嗪或联合应用氢化可的松灌肠治疗溃疡性结肠炎的疗效观察。方法选择我院消化科42例溃疡性结肠炎患者,随机分为两组,对照组应用奥沙拉嗪口服治疗,剂量为1 g,2次/d;观察组为口服奥沙拉嗪,剂量为1 g,2次/d,联合氢化可的松100 mg保留灌肠,1次/d,疗程为4周,观察治疗效果。结果奥沙拉嗪联合氢化可的松灌肠治疗4周后治疗效果优于对照组,差异有统计学意义(P<0.05)。结论奥沙拉嗪联合氢化可的松灌肠治疗溃疡性结肠炎的效果更佳。

Objective Olsalazine and hydrocortisone are useful in the treatment of ulcerative colitis（UC）.The aim of this study was to assess and to compare the efficacy of Olsalazine alone and in combined with hydrocortisone in the treatment of UC patients. Methods A randomized control study was preformed to observe the outcomes of 42 patients with mild UC treated with Olsalazine combined with hydrocortisone. Results The overall efficacy of Olsalazine combined with hydrocortisone was 88.5%.The different between two groups was significant （P〈0.05）. Conclusion Olsalazine combined with hydrocortisone is effective in treating mild UC.