期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

痤疮分子遗传学研究进展

Progress on the molecular genetics of acne
下载PDF
导出
摘要 痤疮是一种多基因遗传决定的毛囊皮脂腺炎症性疾病。目前影响痤疮发病的具体基因仍不清楚。本文将从先天免疫相关基因、类固醇激素、成纤维细胞生长因子受体-2、核转录因子-1和胰岛素样受体-1几个方面阐述痤疮的分子遗传学研究现状。 Acne is a polygenic inheritance disease, which is inflammatory response of hair follicle and sebaceous unit. The effect of specific genes in the pathogenesis of acne remains unclear. The progress on the molecular genetics of acne was reviewed in this paper.
作者 郭冰心 刘玲 王雪 杨智
机构地区 昆明医科大学第一附属医院皮肤性病科 云南省皮肤病研究所
出处 《皮肤病与性病》 2013年第2期82-84,共3页 Dermatology and Venereology
基金 云南省自然科学基金支持 基金号:2009ZC101M
关键词 痤疮 分子遗传学 基因 Acne Molecular genetics Gene
分类号 R394.3 [医药卫生—医学遗传学] R758.733 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献19

  • 1Kumagai Y, Akira S. Identification and functions of pattern-recogni- tion receptors [ J ]. J Allergy Clin Immunol, 2010, 125 ( 5 ) : 985 -992.
  • 2Kim J. Review of the innate immune response in acne vulgaris : activa- tion of Toll-like receptor 2 in ache triggers inflammatory cytokine re- sponses [J]. Dermatology, 2005, 211(3) : 193-198.
  • 3Koreck A, Kis K, Szegedi K, et al. TLR2 and TLR4 polymorphisms are not associated with acne Vulgaris [J]. Dermatology, 2006, 213 ( 3 ) : 267-269.
  • 4Brown RA, Gralewski JH, Razonable RR. The R753Q polymorphism abrogates Toll-like receptor 2 signaling in response to human cytomeg- alovirus [J]. Clin Infect Dis, 2009, 49(9) : e96-99.
  • 5Brown RA, Gralewski JH, Eid AJ, et al. R753Q single-nucleotide polymorphism impairs Toll-like receptor 2 recognition of hepatitis C virus core and nonstmctural 3 proteins [J]. Transplantation, 2010, 89(7) : 811-815.
  • 6Ferwerda B, McCall MB, Alonso S, et al. TLR4 polymorphisms, in- fectious diseases, and evolutionary pressure during migration of modem humans [ J ]. Proc Natl Acad Sci USA, 2007, 104 (42) : 16645 - 16650.
  • 7Baz K, Emin EM, Yazici AC, et al. Association between tumor nec- rosis factor-alpha gene promoter polymorphism at position 308 and ac- ne in Turkish patients [J]. Arch Dermatol Res, 2008, 300(7) : 371 -376.
  • 8Sobjanek M, Zablotna M, Nedoszytko B, et al. Lack of association between the promoter polymorphisms at positions-238 and -308 of the tumour necrosis factor alpha gene and acne vulgaris i n Polish patients [J]. J Eur Acad Dermatol Venereol, 2009, 23(3) : 331-332.
  • 9SzabO K, Tax G, Teodorescu-Brinzeu D, et al. TNFct gene polymor- phisms in the pathogenesis of acne vulgaris [J]. Arch Dermatol Res, 2011, 303 ( 1 ) : 19-27.
  • 10SzabO K, Tax G, Kis K, et al. Interleukin-lA +4845 (G>T) poly- morphism is a factor predisposing to acne vulgaris [ J ]. Tissue Anti- gens, 2010, 76(5) : 411-415.

二级参考文献16

  • 1Rivera R, Guerra A. Management of acne in women over 25 years of age[J]. Actas Dermosifiliogr, 2009, 100 (1): 33-7.
  • 2Cappel M, Mauger D, Thiboutot D. Correlation between serum levels of insulin-like growth factor 1, dehydroepiandrosterone sulfate, and dihydrotestosterone and ache lesion counts in adult women [J]. Arch Dermatol, 2005, 141(3): 333-8.
  • 3Dumont-Wallon G, Dreno B. Specificity of ache in women older than 25 years[J]. Presse Med, 2008, 37(4 Pt 1): 585-91.
  • 4Sharp L, Cardy AH, Cotton SC, et al. CYP17 gene polymorphisms: prevalence and associations with hormone levels and related factors [J]. Am J Epidemiol, 2004, 160(8): 729-40.
  • 5Echibunl B, Perez-Bravo F, Maliqueo M, et al. Polymorphism T→ C (-34 base pairs) of gene CYP17 promoter in women with polycystic ovary syndrome is associated with increased body weight and insulin resistance: a preliminary study[J]. Metabolism, 2008, 57 (12): 1765-71.
  • 6Unsal T, Konac E, Yesilkaya E, et al. Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome [ J ], J Assist Reprod Genet, 2009, 26(4): 205-16.
  • 7Perez MS, Cerrone GE, Benencia H, et al. Polymorphism in CYP11 alpha and CYP17 genes and the etiology of hyperandrogenism in patients with polycystic ovary syndrome [J]. Medicina (13 Aires), 2008, 68(2): 129-34.
  • 8Sobti RC, Gupta L, Thakur H, et aL CYP17 gene polymorphism and its association in north Indian prostate cancer patients [J]. Anticancer Rcs, 2009, 29(5): 1659-63.
  • 9Yang Z, Yu H, Cheng B, et al. Relationship between the CAG repeat polymorphism in the androgen receptor gene and ache in the Han ethnic group[J]. Dermatology, 2009, 218(4): 302-6.
  • 10Rauchhaus M, Gross M, Schulz S, et al. The E-selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty[J]. Int J cardiol, 2002, 83(3): 249-57.

共引文献9

皮肤病与性病
2013年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部