摘要
目的 观察脑复康片治疗老年性痴呆的临床疗效。方法 治疗组60例,对照组60例。治疗组服脑复康片,对照组服淀粉片,每片0.4g,每次2片,每日3次,一疗程为3个月,以MMSE,WMS,HDS评定疗效。结果(1)脑复康片与对照组治疗后MMSE增值分别为2.890±1.400及1.790±1.346(P<0.001),治疗后总的有效率分别为65.00%及6.70%(P<0.001),均有显著差异;(2)HDS增值分别为2.406±1.450及1.070±1.627(P<0.001),总的有效率分别为53.44%及8.30%(P<0.05),亦均有显著差异;(3)脑复康片治疗前后MQ分别为68.20±12.70及72.30±14.30(P<0.001),对照组治疗前后分别为67.20±11.60及68.60±12.10(P<0.01),脑复康片与对照组治疗后复查MQ增值分别为4.191±3.421及1.501±3.976(t=3.78,P<0.001)。二组总的有效率分别为44.84%及10.10%(P<0.05)。脑复康片对VD和AD均有一定的疗效,对VD效果优于AD。
Objective To study the efficacy of the piracetanum to treat dementia in the aged. Methods The double blind piracetanum trial was performed in 120 cases of dementia (Piracetanum 60, VD25, AD29, VD + AD6 ; placebo 60, VD28, AD24, VD + AD 8) in the age with MMSE≤ 24. The dosage of piracetanum (0 .4g/ tab) and starch for each case was 2 tables for 3 months. The effects were evaluted with MMSE、 MQ (WMS) and HDS. Results ①MMSE increment: Piracetanum 2.890 ± 1 .400, starch 1 .790 ± 1 .346(P < 0.01 ); total effective rate: Piracetanum 65.00%, starch 6.70% (P < 0.001 ). ②HDS increment: Piracetanum 2.406 ± 1 .450, starch: 1 .070 ± 1 .627 (P < 0.001 );Total effective rate: Piracetanum 53 .44%, starch 8 .30% (P < 0.05). ③ MQ increment: Piracetanum 4.191 ± 3 .421, starch 1 .501 ± 3 .976 (t = 3.78, P < 0.001 ); total effective rate: Piracetanum 44 .84%, starch 10. 10% (P < 0.05). ④Similar effects were observed in VD and AD with slightly better results in VD. No significant side effects were observed. ⑤The mechanism of Piracetanum to improve cognitive function in the demented may be related to its effects to enhance neuron growth, to increase acetylcholine and to decrease glutamine level in the brain as confirmed in cell and animal experiment, and to improve free radical metabolism and microcirculatory state as confirmed clinically. Conclusions Piracetanum is effective and safe to treat dementia (AD、VD) in the elderly.
出处
《老年医学与保健》
CAS
2000年第3期137-139,共3页
Geriatrics & Health Care