善得定和垂体后叶素联用硝酸甘油治疗食管胃底静脉曲张破裂出血的对比研究

Comparative study on sandostatin and pituitrin together withnitroglycerin in the treatment of esophageal varices bleeding

目的探讨善得定治疗食管胃底静脉曲张破裂出血的疗效。方法所有患者均为肝硬变或肝癌所致食管胃底静脉曲张破裂出血 ,都有呕血和黑便 ,并经胃镜检查证实。共40例分两组 ,善得定组21例 ,垂体后叶素联用硝酸甘油19例 ,分别观察12h、24h及72h的止血效果 ,并比较再出血率 ,药物副作用。结果两组3天止血率分别为善药组90 5 % ,联药组84 2 % ,两组无显著差异。p>0 05。但24h止血率善药组为70 9 % ,联药组为57 5 % ,善药组明显优于联药组。副反应发生率明显低于联药组p<0 05。而且病人有很好的耐受性 ,且不影响再出血的病情观察。结论善得定是治疗食管胃底静脉曲张破裂出血的有效药物。

Objective: To study the effects of sandostatin compared with pituitrin together with nitroglycerin on esophageal varices bleeding. Methods:All patients with esophageal varices bleeding was resulted in liver cirrhosis and liver carcinoma .They have symptoms of heamatemesis and melaena,and have been confirmed by gastrocopy.Patients with esophageal varices bleeding(n=21) were treated with sandostatin (0.1mg iv st,24ug/h ivgtt 0～24h,0.1mg/8h i·h 24～72h),and 19 cases of esophageal varices bleeding were treated with pituitrin together with nitroglycerin(PTT 10u iv st;PTT 7.2u/h No 1.2mg/h ivgtt 0～72h).We compared the hemostatic effect,the rebleeding rate and drug by effect of two groups at 12h,24h and 72h separately.Results:the hemostatic rate between the sandostatin group(the test group 90.5%) and the comparative (84.2%) havent marked difference (p>0.05) after seventy two hours.But the hemostatic rate was 70.9%in sandostatin group better than pituitrin togetter with nitroglycerin (57.5%,p<0.05) after twenty four hours.The by effect rate of the test group was much lower than that of the comparative(p<0.05).Conclusions:Sandostatin is an effective drug in the treatment of esophageal varices bleeding.[