中药药效的物质基础和作用机理研究新思路(一)——中药中化学物种形态和生物活性关系的研究

New Thinking About Study of Pharmacodynamic Material Basis and Functional Mechanism in Chinese Materia Medica —Study on the Relation between Morphology and Biological Activity of Chemical Species in Chinese Mate

中药 (单味药、复方 )药效的物质基础和作用机理研究是中药科学化和现代化的关键。在回顾国内外研究现状的基础上 ,提出中药有效化学成分 (ECC)研究应根据中药ECC的配位化学学说 ,以中药中的化学物种形态为核心 ,以有机成分 (OC)和微量元素 (TE)的相互作用为基础 ,来开展中药ECC的研究工作 ,才能真正解决有效化学成分在中药中的地位和实质 ,才能正确和全面认识中药ECC的生物活性 ,从而为筛选、开发中药配合物新药提供正确思路。据此 ,还介绍了中成药重金属的生物活性和毒性研究方法 ,证明仅仅依据测定其重金属含量评判毒性和制定限量标准是不科学的 ,应当以重金属的物种形态及其与有机成分的配合作用为基础开展相关研究 ,才能制定出科学的、可信的重金属限量标准。

The study on pharmacodynamic material basis and functional mechanism in Chinese materia medica(individual drugs and compound drugs)is a key for [CM(22]scientization and modernization of Chinese materia medica.In review of the current situation and previous study at home and abroad,the author put forward that the study on effective chemical composition(ECC)in Chinese materia medica should be conformed to the theory of coordinate chemistry,with the morphology of chemical species in Chinese materia medica as a core and based upon the mutual function of organic composition(OC)and trace elements(TE),for solving the position and substance of the effective chemical composition in Chimese materia medica and correctly understanding the biological activity of the compatible substance it forms,so as to provide a correct thinking route in the screening and development of the new drugs of compatible substances in Chinese materia medica.Therefore,the author also introduced the study methodology for the biological activity and toxicity of heavy metal in Chinese patent medicines and proved that the standard to assess toxicity just by determination of their heavy metal contents is not scientific.The author insisted that only by the related study based upon the coordinate function of the morphology and effective composition of the heavy metal species,can the scientific and reliable criteria for quantity limitation of heavy metal be stipulated.