环氧合酶-2蛋白在结肠疾病中的表达

Expression of Cyclooxygenase-2 Protein in Colon Diseases

背景：长期使用非甾体类抗炎药（NSAIDs）的患者结肠癌发病率明显下降，NSAIDs能抑制环氧合酶（COX），COX－2在结肠癌的发生过程中起有作用。目的：调查COX－2在结肠病变中的表达。方法：用免疫组化方法检测正常和病变结肠组织中COX－2和COX－1蛋白的表达。结果：COX－2蛋白在正常结肠组织中呈低强度表达，在炎症性肠病（IBD）、结肠腺瘤和结肠癌组织中表达强度明显增高。COX－1蛋白在正常结肠粘膜、IBD、结肠腺瘤和结肠癌组织的上皮细胞和间质细胞中均呈低强度表达。结论：COX－2在结肠肿瘤和IBD的发生中可能起有某种作用。

Background/Aims: Long-term administration of nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the incidence of colon adenocarcinoma by targeting cyclooxygenase (COX) activity. The inducible COX-2 may play a role in colon carcinogenesis. The purpose of this study was to investigate the expression of COX-2 protein in normal and diseased coion. Methods: COX-2 and COX-1 protein expression were examined by immunohistochemistry in tissue spesimens of normal and diseased colon.Results: COX-2 protein was strongly expressed in the epithelial cells of inflammatory bowel disease (IBD), sporadic colonic adenomas and colon adenocarcinomas, while detectable in low level in normal colon. COX-1 protein expression was restricted to some interstitial cells and rarely seen in the epithelial cells of normal and diseased colon. Conclusions: Aberrant COX-2 expression may contribute to the development of IBD and colon carcinogenesis.