帕罗西汀治疗肠易激综合征患者的情绪障碍及腹部症状

Paroxetine in the Treatment of Irritable Bowel Syndrome

目的：探讨选择性5-羟色胺再摄取抑制剂（SSRI）帕罗西汀治疗肠易激综合征（IBS）的疗效，以及IBS患者精神症状与腹部症状的关系。方法：36例有精神障碍表现的IBS患者服用帕罗西汀治疗8周，治疗前后分别对患者行汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）和胃肠道症状计分标准（GSRS）评分并分析3种评分的相关性。结果：IBS患者服用帕罗西汀治疗前后的HAMD、HAMA和GSRS评分存在显著差异（P＜0．001），治疗后患者的精神症状和腹部症状均明显改善。HAMD／HAMA和GSRS评分间有一定相关性，即IBS患者的情绪障碍与腹部症状有一定相关性。结论：帕罗西汀治疗IBS疗效明显，提示5-羟色胺的改变在IBS发病机制中具有重要作用。

Background/Aims: To investigate the effect of selective serotonin reuptake inhibitor (SSRI) on irritable bowel syndrome (IBS) and the relevance of psychological factors and abdominal symptoms in IBS patients. Methods: SSRI paroxetine was used for a period of 8 weeks. The psychological status of 36 IBS patients was analyzed with Hamilton depression (HAMD), Hamilton anxiety (HAMA), and subjective symptoms with gastrointestinal symptoms rating scale (GSRS) before and after the treatment. Results: The scores of HAMD, HAMA and GSRS of IBS patients improved significantly after the treatment (P< 0.001), psychological and abdominal symptoms were also improved. There was a positive correlation among HAMD/HAMA and GSRS. Conclusions: Serotonin may play an important role in the development of psychological and abdominal symptoms of IBS, and paroxetine is effective in its treatment.