摘要
磷脂酰肌醇3-激酶/丝苏氨酸蛋白激酶(PI3K/Akt)是一类特异性催化磷脂酰肌醇(PI)的激酶,其信号途径是细胞内重要的信号转导通路之一,广泛参与动物机体的新陈代谢过程。本文就PI3K/Akt信号途径的结构、活化机制及其在细胞凋亡和肌肉生长发育中的调控机制进行综述。
Phosphatidylinositol 3-kinase/serine-threonine kinase （PI3K/Akt） is a kind of kinases which specifically catalyzes phosphatidylinositol. PI3K/Akt signaling pathway is one of the most important signaling pathways in cells and it is implicated in a broad spectrum of cell metabolism in animals. This review summarized characteristics and activation mechanism of PI3 K/Akt signaling pathway, and discussed the regulation mechanisms in cell apoptosis and muscle growth and development.
出处
《动物营养学报》
CAS
CSCD
北大核心
2013年第4期692-698,共7页
CHINESE JOURNAL OF ANIMAL NUTRITION
基金
国家自然科学基金(31101253
30972112)
关键词
磷脂酰肌醇3-激酶
丝苏氨酸蛋白激酶
信号途径
细胞凋亡
肌肉生长发育
phosphatidylinositol 3-kinase
serine-threonine kinase
signaling pathway
cell apoptosis
muscle growth and development
