原发性肝癌患者血可溶性E-钙粘连蛋白检测的意义

The expression of serum soluble E-cadherin in primary hepatic carcinoma and clinical significance

目的探讨血清可溶性E-钙粘连蛋白（sEC）在原发性肝癌中的表达及其临床意义。方法检测2008年9月至2009年12月间50例原发性肝癌患者、30例肝良性占位病变患者和30例健康人sEC水平，分析sEC水平与临床病理特征的关系。结果原发性肝癌患者sEC水平显著高于肝良性占位病变患者和健康人，sEC水平与原发性肝癌TNM分期密切相关（P〈0.01），与肿瘤分级、有无门静脉癌栓、有无包膜相关（P〈0．05），与年龄、肿瘤大小无关（P〉0．05）。结论sEC可以作为原发性肝癌的血清肿瘤标志物，且sEC水平与原发性肝癌临床分期有关，sEC可作为一种判断原发性肝癌预后预测因子。

Objective To explore the expression and significances of serum soluble E-cadherin （sEC） in primary hepatic carcinoma （PHC）. Methods ELISA assay was utilized to detect the serum level of sEC in PHC patients （n = 50）, hepatic benign space-occupying lesions （n = 30）, and healthy people （n = 30）. The correlation between sEC level and clinically pathological characteristics was analyzed. Results The levels of sEC in PHC patients were significantly higher than those in two controls. The sEC levels showed significant correlation with TNM staging （P〈0. 01）, and with Edmondson grade, carcinoma thrombi within portal vein and carcinoma tissue capsule in PHC patients （P〈0. 05）, instead of age of patients and tumor size （P〉0. 05）. Conclusion Carcinoma, hepato cellular; Soluble E-cadhein; Tumor markers, biological