改良序贯疗法联合荆花胃康丸根除幽门螺杆菌的临床观察

The clinical research of improved Sequential Therapy Combined with Jinghuaweikang Capsules in the treatment of Helicobacter pylori eradication

[目的]观察改良序贯疗法联合荆花胃康丸根除幽门螺杆菌(Hp)的疗效与安全性。[方法]选择102例Hp阳性消化性溃疡(PU)患者,随机分为治疗组和对照组各51例,治疗组给予改良序贯疗法加荆花胃康胶丸治疗,对照组给予标准三联疗法,观察2组总体症状缓解率、停药4周后Hp根除率、不良反应。[结果]治疗组Hp根除率为94.12%,对照组Hp根除率为74.51%(P<0.05),主要症状的改善治疗组明显优于对照组,不良反应发生率分别为4.35%和26.09%(P<0.05)。[结论]改良序贯疗法联合荆花胃康丸能够显著提高Hp根除率,症状缓解快,不良反应发生率低,患者依从性和耐受性提高,疗效安全、可靠。

[Objective]To observe the clinical efficacy and safety of improved sequential therapy com- bined with Jinghuaweikang Capsules on eradicating Helicobacter pylori （Hp）. [Methods]One hundred and two patients with Hp-positive peptic ulcer were selected, of whom 51 were given improved sequential thera- py combined with Jinghuaweikang Capsules as the treatment group, and 51 were given only the triple thera- py as the control group. After treatment, patients in each group were observed Hp eradication rate, effec- tiveness and efficiency of clinical symptom improvement and the adverse reactions. [Results] The Hp eradi- cation rate was 94. 12~/00 in the treatment group,which was raised significantly from 74.51~ in the control group （P〈0. 05）. The improvement of main symptoms was better in the treatment group than the control group. The side effect occurrence was 4. 35% and 26.09%, respectively in the two groups （P〈0. 05）. [Conclusion]The improved sequential therapy combined with Jinghuaweikang Capsules has higher eradica- tion rate on Hp in.patients with Hp-positive peptic ulcer. It can relieve patients＇ symptoms quickly with low side effect occurrence and good compliance.