中西医结合治疗肝硬化的临床研究

Clinical study of liver cirrhosis treated by integrated traditional Chinese and western medicine

[目的]观察中西医结合治疗肝硬化的临床疗效。[方法]随机选取我院就诊的200例肝硬化患者进行病例对照研究,随机分为对照组和试验组,各100例,对照组按照西医分型治疗;试验组明确中医辨证分型,在对照组治疗基础上给予中药调理,患者出院后对其进行随访观察,综合评价患者的治疗效果。[结果]对照组的总有效率为65.0%,无效率35.0%,试验组的总有效率92.0%,无效率8.0%,2组比较,差异有统计学意义(P<0.05)。试验组治疗前后血清肝纤维化指标:透明质酸为(478.1±210.8)和(306.1±130.5)μg/L;层黏连蛋白(130.1±32.8)和(99.0±21.5)μg/L;Ⅲ型前胶原(195.1±32.8)和(145.1±18.6)μg/L,治疗前后比较差异均有统计学意义(P<0.05)。[结论]中医辨证结合西医常规治疗肝硬化临床效果和随访结果均优于单纯西医治疗,同时辅以针灸疗法,对防止患者病情的进一步发展效果更明显。

[Objective]To observe the clinical efficacy of liver cirrhosis treated by integrated traditional Chinese and western medicine therapy. [Methods]A total of 200 patients with liver cirrhosis were randomly divided into treatment and control groups （n= 100）. Patients in control group received western medicine, while those in treatment group received Chinese blood lipids as well as B ultrasound and symptoms medicine in addition. Evaluation of liver function and of indicators before and after treatment wore performed.[Results]The total effective rate was 65% in control group and 92 % in treatment group, showing signifi- cant difference （P〈0. 05）. The hyaluronic acid level in treatment group before and after treatment was re- spectively（478. 1±210.8）μg/L and （306.1±130.5）μg/L, laminin was （130. 1±32.8）μg/L and（99.0±1.5）μg/L, and type Ⅲ procollagen was （195.1±32.8）μg/L and（145.1±18.6）μg/L, all indicating sig- nificant difference （P〈0.05）. CConlusion]Treatment of integrated traditional Chinese and western medi- cine has a superior effect on liver cirrhosis. Supplementation of acupuncture and moxibustion can help pre- vent further development of the disease.