Sox2在人肾癌组织中的表达及其临床意义

Correlation between Sox2 expression and clinical significance in patients with renal carcinoma

【目的】观察性别决定区因子(SRY-related high-mobility group box 2,Sox2)在人肾癌组织中的表达,探讨Sox2的表达与临床病理因素和预后的相关性。【方法】运用免疫组化Envision法检测156例人肾细胞癌及其配对癌旁正常肾组织病理标本中Sox2的表达水平,采用SPSS13.0统计软件分析肿瘤组织Sox2与临床病理因素及患者总生存时间的关系。【结果】Sox2在人肾癌组织中的表达明显高于癌旁正常组织(P<0.05);随TNM分期的递增(P=0.027)、淋巴结转移的出现(P=0.010)以及Ki-67表达(P=0.037)的增加,Sox2表达水平逐渐升高,各组间有显著相关性;Sox2表达阳性的肾癌患者,术后五年生存率较低(P=0.017);Sox2的表达与患者性别、年龄、肿瘤直径及组织类型无显著相关性。【结论】Sox2的表达与临床病理因素及预后有一定关系,其高表达可能在肾癌发生、发展中起重要作用,并很可能成为潜在的治疗靶点及预测肾癌预后的有价值的分子标记物。

[Objective] To investigate the correlation between SRY-related high-mobility group box 2 （Sox2） expression and clinicopathological factors and prognosis in patients with human renal cell carcinoma. [ Methods] Using immunnohistochemistry to analyze the Sox2 expression in 156 cases of human renal cell carcinoma and adjacent normal renal tissue. The relationship of Sox2 expression and clinicopathological factors were analyzed using statistical software SPSS 13.0. [Results] The expression of Sox2 in renal carcinoma was significantly higher than that in adjacent normal tissues （P 〈 0.05）. The Sox2 expression was significantly correlated with increments of TNM staging （P=0.027）, appearance of maxillary lymph node matastasis（P = 0.010）,and the increase of Ki-67 positive （P = 0.037）. Each groups has statistical significance; The positive expression of Sox2 in patients with renal carcinoma has a lower five-year survival rate （P = 0.017）. The expression of Sox2 was not correlated with sex and age of the patients, tumor size and histological grade. [Conclusions ]The high expression of Sox2 may be involved in the occurrence and development process of renal carcinoma; The expression of Sox2 has a certain relationship with clinicopathological factors in renal carcinoma, which it is likely to be a potential therapeutic target and a valuable prognostic indicator in renal carcinoma progression.