2型糖尿病患者甲状腺激素异常的临床分析

Clinical analysis of thyroid hormone in patients with type 2 diabetes mellitus

【目的】分析2型糖尿病患者和健康对照组甲状腺疾病患病率情况,探讨糖尿病和甲状腺疾病的关系。【方法】选取2010年1月-2012年5月住院的2型糖尿病患者527例和在此期间我院体检的健康人274人,测定FT3、FT4、TSH、TPOAb、TGAb。【结果】在健康对照组中,甲状腺功能异常者患病率10.2%,男性为2.9%,女性为7.3%;TPOAb阳性率为9.85%,TGAb阳性率为6.20%。在2型糖尿病患者中,甲状腺功能异常者患病率13.09%,男性为4.9%,女性为8.2%;TPOAb阳性率为15.18%,TGAb阳性率为6.64%。【结论】2型糖尿病患者甲状腺疾病患病率较健康对照组明显增加,以女性亚临床甲减为主;定期监测FT3、FT4、TSH对糖尿病患者的病情的评估、预后的判断和指导治疗具有重要的临床意义。

[Objective]To analyze the patients with type 2 diabetes mellitus and healthy thyroid disease prevalence in control group to explore the relationship between diabetes and thyroid disease. [ Method ] 527 cases of type 2 diabetes mellitus（hospitalized on January 2010 May 2012 ）and 274 healthy people during this period in our hospital physical examination, determination FT3, FT4, TSH, TPOAb, TGAb. [ Results ] In the healthy control group, thyroid dysfunction prevalence 10.2%, male 2.9%, female 7.3%; Positive rate of TPOAb is 9.85%,TGAb is 6.2%. In patients with type 2 diabetes mellitus, thyroid dysfunction prevalence 13.09%, male 4.9%, female 8.2%; Positive rate of TPOAb is 15.18% ,TGAb is 6.64%. [Conclusion] The prevalence of thyroid disease in type 2 diabetic patients compared with healthy control group increased significantly, mainly in female subclinical hypothyroidism; regular monitoring FT3, FT4, TSH on the assessment of the diabetic patient＇s condition, prognosis and guiding treatment has an important clinical significance.