川崎病并心血管外脏器损害9例临床分析

CLINICAL ANALYSIS OF NINE PATIENTS WITH KAWASAKI DISEASE INVOLVED VISCERA DAMAGE BESIDES CARDIOVASCULAR SYSTEAM

目的了解川崎病并发心血管外脏器损害患儿的临床特点。方法对我院2009年5月—2011年7月收治的9例川崎病并心血管外脏器损害患儿的临床资料进行回顾性分析,并总结其临床特点。结果 9例川崎病患儿,男5例,女4例;年龄3个月～7岁。其中2例并发无菌性脑膜炎,1例同时并发中毒性肠麻痹;4例并发肺部炎性侵润,1例同时并发胆囊炎性侵润,4例皆存在肝功能损害;3例并发腹泻,大便镜检:RBC(++)^(+++),WBC(+)^(+++),其中2例同时存在肝功能损害,另1例同时存在急性期尿道炎表现。结论川崎病除易并发冠脉病变外,其他系统如:神经系统、骨关节系统、消化系统、呼吸及泌尿系统亦常受累,且多出现在疾病早期,可为其早期主要临床表现。了解其临床特点,有利于早期诊断、早期用药及减少多脏器损害。

Objective To understand the clinical characteristics of Kawasaki disease involved viscera damage besides cardiovascular system. Methods Nine cases with Kawasaki disease involved viscera damage besides cardiovascular system were enrolled during the period from May. 2009 to Jul. 2011, whose clinical data were analyzed retrospectively and clinical characteristics were summarized. Results Among nine patients, in- cluded 5 boys and 4 girls, aged 3 months to 7 ages. Two of nine cases associated with asceptic meningitis and one of them was also with toxic paralytic ileus. Four of nine cases associated with inflammation lesion of the lungs and one of them was also with inflammation lesion of the gallbladder. All of 4 cases had liver damage. Three of nine cases associated with diarrheal diseases, stool microscopy： RBC （＋＋） ~ （H~）,WBC （ ＋ ） ~ （~r）, in them, two with liver damage and one with acute urethritis. Conclusions Besides coronary damage as the common complication of Kawasaki disease, other systems including nerve system, bone and joint system, digestive system, respiratory system and urinary system are also easily damaged, and all the damages often occurre in the early stage. To understand the clinical characteristics is helpful to early diag- nosis, medicine application and reduce multi- organ injury.