灯盏花素温敏型鼻用原位凝胶的基质处方筛选

Study on Formulation of Breviscapine in Situ Nasal Thermoreversible Gel

目的:确定灯盏花素温度敏感型鼻用原位凝胶的基质处方。方法:以泊洛沙姆407和泊洛沙姆188作为温敏材料考察对象,采用搅拌子法测定溶液-凝胶相变温度,以单因素结合均匀设计优选基质处方。结果:确定质量分数19%泊洛沙姆407和4%泊洛沙姆188的组合作为灯盏花素温度敏感型原位凝胶的基质,其胶凝温度为32.9℃,与鼻腔温度接近。结论:选定的灯盏花素温敏型原位凝胶基质,适宜用于鼻腔给药。

Objective：To prepare a Breviscapine in situ nasal thermoreversible gel.Methods：With Poloxamer 407 and Poloxamer 188 as gel base,the gelation temperature was investigated by stirrer.Results：19% Poloxamer 407 and 4% Poloxamer 188 were established as the best compositions of the gel base,and its gelation temperature was 32.9 ℃,which was suitable for drug delivery system of nasal.Conclusion：The temperature of Brethermosensitive gel was close to the temperature of asal cavity,so it is suitable for drug delivery system of nasal cavity.