中西医治疗先兆流产对TNF-α的影响及妊娠结局分析

Impact of Traditional Chinese and Western Medicine in Treatment of Threatened Abortion on TNF-α and Pregnancy Outcome Analysis

目的:观察90例先兆流产患者保胎治疗后的妊娠结局,了解治疗前后血清肿瘤坏死因子—α(TNF-α)的变化,并探讨其与妊娠结局的相关性。方法:采用酶联免疫吸附法(ELISA)检测治疗前后患者血清中TNF-α的水平,并随访药物保胎治疗后继续妊娠者,了解其最终妊娠结局。结果:治疗前后患者TNF-α的变化有统计学意义(P<0.05);良好妊娠结局者与不良妊娠结局者治疗前TNF-α比较,没有统计学意义(P>0.05);良好妊娠结局者与不良妊娠结局者治疗后TNF-α比较,具有统计学意义(P<0.05)。结论:先兆流产患者经保胎治疗后母体外周血中TNF-α水平下降;TNF-α的异常表达与先兆流产的发病有关;先兆流产患者血清TNF-α水平的变化与妊娠结局有一定的相关性。

Objective：To observe the changes of serum tumor necrosis factor-α（TNF-α）in 90 threatened abortion patients before and after treatment,and to further explore the correlation with pregnancy outcome.Methods：Enzyme-linked immunosorbent assay（ELISA）was used to measure TNF-α levels in serum before and after treatment,and patients of pregnancy after drug treatment were followed up to understand the final outcome of pregnancy.Results：The changes of TNF-α levels in serum before and after treatment were statistically significant（P0.05）;TNF-α levels of good pregnancy outcome and bad pregnancy outcome were compared before treatment,there was no statistical significance（P0.05）;compared after treatment,there was statistical significance（P0.05）.Conclusion：TNF-α levels of maternal peripheral blood of threatened abortion patients after Baotai therapy decreased.The abnormal expression of TNF-α is related to threatened abortion pathogenesis.The changes of serum TNF-α levels have certain correlation with pregnancy outcome.