何首乌及其制剂致药物性肝损伤52例临床分析

Clinical Analysis of 52 Patients with Liver Injury Induced by Ploygonum Multiflorum and Its Preparation

目的:分析何首乌致药物性肝损伤的临床特点,以期引起临床的重视。方法:回顾性分析因口服何首乌及其制剂导致药物性肝损伤的52例住院患者的临床资料。结果:从服药到发病最短5天,最长4个月,大多在2周;肝损伤类型:肝细胞损伤型30例(占58%),胆汁淤积型9例(占17%),混合型13例(占25%)。全部患者经停用何首乌及其制剂、积极护肝等治疗痊愈出院。结论:在临床工作中应规范使用何首乌及其制剂,对应用何首乌及其制剂者应严密监测肝功能,一旦发现肝损伤,及时停药并给予护肝治疗,大多预后良好。

Objective：To analyze the clinical characteristics of 52 patients with liver injury induced by Ploygonum multiflorum and its preparation,and to lead to the clinical attention.Methods：The clinical data of 52 hospitalized patients with liver injury induced by Ploygonum multiflorum and its preparation from June 2006 to June 2012 were analyzed retrospectively.Results：The earliest onset time of liver injury was 5 days,the latest was 4 months.With clinical manifestation,30 cases（58%）of patients were classified as hepatocellular injury type,9 cases（17%）as cholestatic type and 13 cases（25%）as mixed type.All patients were cured and discharged from hospital by stopping the induced drugs and the related liver-protected treatments.Conclusion：We should regulate the use of Ploygonum multiflorum and its preparation in clinical work.If using these Chinese herbs,we should closely monitor liver function.Once liver injury occurs,we should timely stop the induced drugs and give related liver-protected treatments,and most patients have good prognosis.