黄芪注射液治疗变异型心绞痛及对内皮功能的影响

Effect of Astragalus Injection in Treatment of Variant Angina Pectoris and Its Influence on Endothelial Function

目的:评价黄芪注射液治疗变异型心绞痛的疗效及对患者内皮素-1(Endothelin-1,ET-1)及一氧化氮(Nitric oxide,NO)水平的影响。方法:60例变异型心绞痛患者,按随机数字表法分为观察组和对照组。对照组:采用硝苯地平片、阿司匹林肠溶片及阿托伐他汀钙片治疗。观察组:在对照组方法的基础上,加用黄芪注射液治疗变异型心绞痛。结果:观察组总有效率86.67%高于对照组总有效率63.33%,差异有统计学意义(P<0.05)。与对照组相比,观察组能明显改善ET-1及NO水平,统计学处理,差异有显著性(P<0.01)。与对照组相比,观察组能明显降低心脏事件的发生率,统计学处理,差异有显著性(P<0.05)。结论:黄芪注射液用于治疗变异型心绞痛疗效可靠,并能明显改善变异型心绞痛患者的ET-1及NO水平。

Objective：To made therapeutic evaluation of Astragalus Injection in the treatment of variant angina pectoris and its influence on Endothelin-1（ET-1） and nitric oxide（NO）.Methods：60 cases of patients with variant angina pectoris were divided into the observation group and the control group.The control group：nifedipine tablets,enteric-coated tablets of aspirin and atorvastatin calcium tablets treatment of variant angina pectoris.The observation group：on the basis of the control group method,added Astragalus Injection in the treatment of variant angina pectoris.Results：The total efficiency of the observation group was 86.67% which was higher than 63.33% of the control group,with significant difference（P0.05）.Compared with the control group,the observation group can improve the levels of ET-1 and NO,with statistically significant difference（P0.01）.Compared with the control group,the observation group could reduce the incidence of cardiac events,with statistically significant difference（P0.05）.Conclusion：Astragalus Injection has reliable curative effect for the treatment of variant angina pectoris,and can obviously improve the ET-1 and NO of patients with variant angina.