支气管扩张症发病机制及治疗进展

Pathogenesis and treatment of bronehieetasis

支气管扩张症在世界范围内发病率均有所增加，但其异质性较强，目前对其病因、发病机制及有效治疗等方面的研究相对较少，我们对这一疾病还有待进一步认识。目前认为其发病机制主要有免疫失调及细菌定植两个方面。近来大环内酯类抗生素对支气管扩张症的治疗方面也取得了一些进展。本文就非囊性纤维化支气管扩张症流行病学、病因学、发病机制及治疗方面的进展进行综述。

The incidence of bronchiectasis is increased in the worldwide recently. Since it is a very heterogeneous condition, we still know little about the etiologic factors, pathogenesis and treatment of bronchiectasis. The main factors are immune dysfunction and bacterial colonisation. Recent evidence has shown the efficacy of macrolides in the treatment of bronchiectasis. This review focuses on the recent advances in the prevalence,etiology, pathogenesis, and treatment of non-cystic fibrosis bronchiectasis.