前瞻性观察妊娠期糖尿病新诊断标准对孕妇妊娠结局的影响

Prospective study of adverse pregnancy outcomes by using new diagnostic criteria of gestational diabetes mellitus

目的探讨新、旧妊娠期糖尿病(GDM)新诊断标准对孕妇妊娠结局的影响。方法采用前瞻性研究法,分析旧诊断标准漏诊为GDM而新标准确诊为GDM患者100例,随机分两组,干预组50例,给予饮食、运动疗法及口服降血糖药物等治疗;对照组50例,不给予任何控制血糖的治疗措施,比较两组妊娠结局的差异。结果干预组孕妇子痫前期、妊娠期高血压、羊水过多、早产及胎儿发育异常、新生儿低血糖等的发生率分别为6.00%、2.00%、2.00%、4.00%、2.00%和2.00%,均显著低于对照组(20.00%、12.00%、10.00%、13.33%、12.00%和10.00%),两组比较差异具有统计学意义(P<0.05)。结论妊娠期糖尿病新诊断标准可更好地管理高危孕妇,减少不良妊娠结局的发生,具有重要临床意义。

[ Objective ] To investigate the influence of Old and New Diagnostic Criteria of Gestational Diabetes Mellitus on adverse pregnancy outcomes. [ Methods ] 100 cases of pregnant women were selected missed GDM of the old standard and adopt the new standard for with GDM diagnosed, randomLy divided into two group, intervention groups （50 cases ） were given Diet, exercise therapy and hypoglyeemic drug, while it was nothing treatment on control group.The adverse pregnancy outcomes was compared in the two groups. [ Resluts ] The rate of maternal preeclampsia, gestational hypertension, Diet and exercise therapy,premature, fetal abnormalities and neonatal hypoglycemia was 6.00%,2.00%,2.00%,4.00%,2.00% and 2.00% in observation groups, it was significance lower than control group（20.00%,12.00%,10.00%,13.33%,12.00% and 10.00%）（P〈0.05）. [ Conclusions ] The new diagnostic criteria accepted more pregnant women missed by the old standard into the diagnosis, and to give management to them can reduce the occurrence of adverse pregnancy outcomes.