保定市2010年麻疹减毒活疫苗强化免疫疑似预防接种异常反应分析

Analysis on adverse events following immunization of measles attenuated live vaccine after supplementary immunization activities in Baoding in 2010

目的分析麻疹减毒活疫苗(measles attenuated live vaccine,MV)强化免疫活动(supplementary immunizationactivities,SIA)疑似预防接种异常反应(adverse events following immunization,AEFI)发生情况。方法对保定市2010年的MV,SIA,AEFI开展监测和分析。结果全市共报告AEFI 157例,报告发生率8.28/10万剂;男性多于女性,发生率随年龄增加逐渐降低;一般反应报告发生率4.91/10万剂;异常反应报告发生率2.90/10万剂,以过敏性皮疹为主(1.69/10万剂),其次为过敏性紫癜(0.90/10万剂);64.84%发生在接种后≤1d。结论 MV的安全性良好,接种MV后<1d是监测的重点。

Objective To analyze the adverse event following immunization （AEFI） of measles attenuated live vaccine （MV） after supplementary immunization activity （SIA） . Method Monitor and analyze the data of AEFI in Baoding in 2010. Results 157 cases of AEFI were reported, and the incidence was 8.28/100 000. Male cases were larger than female ones. The incidence reduced along with age. The incidence rates of common event and adverse event were 4. 91/100 000 and 2.90/100 000. Most adverse cases were anaphylactic rash （ 1.69/100 000 ） , followed by anaphylactoid purpura （ 0. 90/100 000 ） . 64. 84% of cases occurred within 1 days after immunization. Conclusions MV has good safety, and people should be observed within 1 day after vaccination.